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Role of endothelial nitric oxide synthases system on acute appendicitis

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dc.contributor.authorTASLIDERE, BAHADIR
dc.contributor.authorŞENER, Elif Funda
dc.contributor.authorTaslidere, ELİF
dc.contributor.authorGUNAY, Nahide Ekici
dc.contributor.authorBOL, Oguzhan
dc.contributor.authorBULBUL, Emre
dc.contributor.authorAktas, Ramazan Sami
dc.contributor.authorGÜNAY, Nurullah
dc.contributor.institutionauthorTAŞLIDERE, BAHADIR
dc.contributor.institutionauthorTAŞLIDERE, ELİF
dc.date.accessioned2019-10-05T13:37:36Z
dc.date.available2019-10-05T13:37:36Z
dc.date.issued2016-07-01
dc.description.abstractBACKGROUND: Obstruction and inflammation of the appendix lumen is the leading physiopathological process during acute appendicitis (AA). Although the relationship between inflammation and endothelial nitric oxide synthases (eNOS) has been well described, no recent data describing the relationship between inflammation during AA and polymorphism of the eNOS gene has been reported. Given the limited data available, we believed that defining the relationship between AA and eNOS would be a beneficial contribution. METHODS: A total of 201 patients admitted to the emergency department with AA and 201 healthy volunteers selected from among the relatives of patients were included. Polymorphism of the eNOS was assessed. RESULTS: Intron 4a/4a was positive in 119 participants, genotype G894T GT was positive in 71 patients with AA, and 786-1 was positive in 71 patients with AA. These results suggest that no statistically significant correlation exists between genotypes of AA patients and control subjects regarding 4a/b, G894-GT, and 786-1 eNOS polymorphisms. CONCLUSION: Though the present results suggest that no statistically significant correlation exists between AA and eNOS gene polymorphism, to claim otherwise is also impractical. We believe that the present results will lay the groundwork for future, larger studies.en
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dc.identifier.citationTASLIDERE B., ŞENER E. F. , Taslidere E., GUNAY N. E. , BOL O., BULBUL E., Aktas R. S. , GÜNAY N., -Role of endothelial nitric oxide synthases system on acute appendicitis-, ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.22, ss.338-343, 2016
dc.identifier.doi10.5505/tjtes.2016.38202
dc.identifier.pubmed27598605
dc.identifier.scopus84975296973
dc.identifier.trdizinISSN: 1306-696X / 1307-7945
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/2558
dc.identifier.wosWOS:000378681000006
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleRole of endothelial nitric oxide synthases system on acute appendicitis
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameDicle tıp dergisi
local.avesis.id3e8bb2ec-4647-42d2-9e2d-02de3f7d21c6
local.avesis.response2428
local.publication.isinternational1
relation.isAuthorOfPublicationc3a1f40b-abfb-41fc-ac37-c541ff5cc173
relation.isAuthorOfPublication1bcd2ccf-c1aa-4999-a863-1d634b1c7fe6
relation.isAuthorOfPublication.latestForDiscoveryc3a1f40b-abfb-41fc-ac37-c541ff5cc173
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