Publication: Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults
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Smith L.
López Sánchez G. F.
SOYSAL P.
Veronese N.
Rahmati M.
Kostev K.
Jacob L.
Tully M. A.
Richardson F.
Butler L.
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Abstract
Objectives: Dynapenic abdominal obesity (DAO) may potentially increase risk for mild cognitive impairment (MCI), but data is scarce, and community-based studies are lacking. Thus, we aimed to investigate the association between DAO and MCI in a large nationally representative community-based sample from six LMICs (China, Ghana, India, Mexico, Russia, South Africa). Methods: We analyzed cross-sectional data from the Study on Global Ageing and Adult Health. Dynapenia was defined as handgrip strength of 88 cm for women and > 102 cm for men. DAO was defined as having both dynapenia and abdominal obesity. The National Institute on Ageing-Alzheimer’s Association criteria were used to define MCI. Multivariable logistic regression was performed. Results: Data on 32,715 individuals aged ≥ 50 years were analyzed [mean (SD) age 62.1 (15.6) years; 48.3% males]. Among those aged 50–64 years, dynapenia alone and DAO were significantly associated with MCI with the OR for DAO (OR = 1.79; 95%CI = 1.26–2.56) being higher than that of dynapenia alone (OR = 1.40; 95%CI = 1.15–1.71). In those aged ≥ 65 years, only dynapenia alone (OR = 1.53; 95%CI = 1.23–1.89) was significantly associated with MCI but not DAO. Abdominal obesity alone was not significantly associated with MCI in both age groups. Conclusions: Among community-dwellers in six LMICs, DAO was significantly associated with MCI among middle-aged individuals, but not among older people. However, it is important to note that the study was cross-sectional in nature, and thus, it is not known whether DAO leads to MCI or vice versa. Therefore, future longitudinal studies are necessary to clarify temporal associations and possible causality.
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Tıp, Dahili Tıp Bilimleri, İç Hastalıkları, Geriatri, Yaşam Bilimleri, Moleküler Biyoloji ve Genetik, Sitogenetik, Sağlık Bilimleri, Temel Bilimler, Medicine, Internal Medicine Sciences, Internal Diseases, Geriatrics, Life Sciences, Molecular Biology and Genetics, Cytogenetic, Health Sciences, Natural Sciences, Geriatri ve Gerontoloji, Klinik Tıp (Med), Yaşam Bilimleri (Life), Klinik Tıp, Biyokimya ve Moleküler Biyoloji, Geriatrics & Gerontology, Clinical Medicine (Med), Life Sciences (Life), Clinical Medicine, Molecular Biology & Genetics, Biochemistry & Molecular Biology, Yaşlanma, Aging, Geriatrics and Gerontology, Dynapenic abdominal obesity, Low- and middle-income countries, Mild cognitive impairment, Older adults
Citation
Smith L., López Sánchez G. F., SOYSAL P., Veronese N., Rahmati M., Kostev K., Jacob L., Tully M. A., Richardson F., Butler L., et al., "Association between dynapenic abdominal obesity and mild cognitive impairment among middle-aged and older community-dwelling adults", Aging Clinical and Experimental Research, cilt.37, sa.1, 2025