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The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model

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dc.contributor.authorSonmez, ERTAN
dc.contributor.authorÇAVUŞ, Umut Yucel
dc.contributor.authorCİVELEK, Cemil
dc.contributor.authorDUR, Ali
dc.contributor.authorKARAYEL, Eda
dc.contributor.authorGulen, BEDİA
dc.contributor.authorUysal, Omer
dc.contributor.authorİPEK, Gokturk
dc.contributor.institutionauthorSÖNMEZ, ERTAN
dc.contributor.institutionauthorGÜLEN, BEDİA
dc.contributor.institutionauthorUYSAL, ÖMER
dc.date.accessioned2019-10-05T13:49:21Z
dc.date.available2019-10-05T13:49:21Z
dc.date.issued2014-03-01
dc.description.abstractBackground: Bleeding is a major problem in warfarin pretreated patients who need emergency surgical procedures. APH is a hemostatic agent with ultra-hydrophilic and particulate properties. This study aimed to evaluate the in vivo hemostatic effect of APH in rats pretreated with warfarin. Methods: Forty-eight Wistar rats were divided into two main groups: one group was pretreated with warfarin and the other group was not. These two groups were further divided into three subgroups according to the administration of APH, wheat meal, or saline, for a total of six subgroups. Standard full thickness tissue defects were performed on the backs of the rats. Saline, wheat meal, or APH were administered to the bleeding defect site in both main groups. Hemostasis time and amount of bleeding were calculated. Results: The bleeding time in rats administered APH was significantly shorter than those administered wheat meal and saline. Consequently, the amount of bleeding was significantly less in the APH groups than in the control groups. Conclusion: APH has an effective hemostatic property in rats pretreated or non-pretreated with anticoagulants. Hemostatic agents can be useful for incidences of external bleedings, which are increasing because of anticoagulation.en
dc.identifier
dc.identifier.citationSonmez E., ÇAVUŞ U. Y. , CİVELEK C., DUR A., KARAYEL E., Gulen B., Uysal O., İPEK G., -The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model-, ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.20, ss.79-85, 2014
dc.identifier.doi10.5505/tjtes.2014.54938
dc.identifier.pubmed24740331
dc.identifier.scopus84895889687
dc.identifier.trdizinISSN: 1306-696X / 1307-7945
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/3089
dc.identifier.wosWOS:000332686100001
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleThe efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTurk Plastik, Rekonstruktif ve Estetik Cerrahi Dergisi
local.avesis.id4b0a276f-f8c1-4f08-9983-cfe192c66108
local.avesis.response2959
local.publication.isinternational1
relation.isAuthorOfPublication7c2c805b-4458-4223-8538-1b184f1a997a
relation.isAuthorOfPublication60efa820-9e8d-4fb0-b825-94a7233fc775
relation.isAuthorOfPublication19df24c5-c3e8-4158-8eed-717f885c608d
relation.isAuthorOfPublication.latestForDiscovery19df24c5-c3e8-4158-8eed-717f885c608d
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