Publication: Identification of highly conserved, serotype-specific dengue virus sequences: implications for vaccine design
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2019-12-01T00:00:00Z
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Chong, Li Chuin
Khan, Asif M.
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Abstract
Background: The sequence diversity of dengue virus (DENV) is one of the challenges in developing an effective vaccine against the virus. Highly conserved, serotype-specific (HCSS), immune-relevant DENV sequences are attractive candidates for vaccine design, and represent an alternative to the approach of selecting pan-DENV conserved sequences. The former aims to limit the number of possible cross-reactive epitope variants in the population, while the latter aims to limit the cross-reactivity between the serotypes to favour a serotype-specific response. Herein, we performed a large-scale systematic study to map and characterise HCSS sequences in the DENV proteome.
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Chong L. C. , Khan A. M. , -Identification of highly conserved, serotype-specific dengue virus sequences: implications for vaccine design-, BMC GENOMICS, cilt.20, 2019