Publication:
Platelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer

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dc.contributor.authorAcikgoz, Ozgur
dc.contributor.authorCakan, Burcin
dc.contributor.authorDEMİR, Tarık
dc.contributor.authorBilici, Ahmet
dc.contributor.authorOven, Bala Basak
dc.contributor.authorHamdard, Jamshid
dc.contributor.authorOlmuscelik, Oktay
dc.contributor.authorOlmez, Omer Fatih
dc.contributor.authorŞEKER, Mesut
dc.contributor.authorYildiz, Ozcan
dc.contributor.institutionauthorDEMİR, TARıK
dc.contributor.institutionauthorŞEKER, MESUT
dc.date.accessioned2021-12-21T20:59:13Z
dc.date.available2021-12-21T20:59:13Z
dc.date.issued2021-11-01T00:00:00Z
dc.description.abstractThe aim of this study was to investigate the predictive and prognostic value of PLR, and the relationship between PLR and tumor localization. A total of 229 patients with de-novo metastatic CRC were retrospectively analyzed. The cutoff value for PLR was defined by the receiver operating characteristic (ROC) curve analysis and threshold value of 196.5 as best cut-off value was found. The higher rate of BRAF mutation was significantly detected for patients with PLRhigh (> 196.5) compared to those with PLRlow (<= 196.5) (P = .001). PLR was significantly higher in tumors located on the right colon (P = .012). PLR, tumor localization, the presence of surgery for primary tumor, the presence of curative surgery, the presence of metastasectomy for progression-free survival (PFS) and PLR, gender, BRAF mutation, tumor localization, the presence of surgery for primary tumor, the presence of metastasectomy for overall survival (OS) were found to be prognostic factors by univariate analysis. Multivariate analysis showed that PLR, the presence of curative surgery and the presence of metastasectomy for both PFS and OS were found to be independent prognostic factors. Moreover, a logistic regression analysis indicated that PLR and tumor localization were found to be an independent factors for predicting response to systemic treatment (P P = .023 respectively). Our results showed that pretreatment PLR was readily feasible and simple biomarker predicting response to treatment and survival, in addition it was significantly associated with tumor localization.
dc.identifier.doi10.1097/md.0000000000027712
dc.identifier.pubmed34871263
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29826
dc.identifier.wosWOS:000727992700052
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmetastatic colorectal cancer
dc.subjectplatelet-to-lymphocyte ratio
dc.subjectprognostic factor
dc.subjectsurvival
dc.subjecttreatment response
dc.titlePlatelet to lymphocyte ratio is associated with tumor localization and outcomes in metastatic colorectal cancer
dc.typeArticle
dspace.entity.typePublication
local.avesis.idc0c5a90f-06a0-4090-83dd-1d5fe0059164
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication7024abc2-f738-45d1-8283-a6361cda5c3a
relation.isAuthorOfPublication8a03684e-e421-4a9f-9069-168fc121a5d4
relation.isAuthorOfPublication.latestForDiscovery7024abc2-f738-45d1-8283-a6361cda5c3a
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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