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Stability-indicating ultra-fast liquid chromatographic analysis of maprotiline in pharmaceutical formulations

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dc.contributor.authorTEKKELİ, ŞERİFE EVRİM
dc.contributor.authorOnal, Cem
dc.contributor.institutionauthorTEKKELİ, ŞERİFE EVRİM
dc.date.accessioned2020-10-22T20:20:17Z
dc.date.available2020-10-22T20:20:17Z
dc.date.issued2019-07-01T00:00:00Z
dc.description.abstractThis current study aimed to develop a simple, fast, and reproducible isocratic reverse-phase ultra-fast liquid chromatographic (RP-UFLC) method to detect and quantify maprotiline hydrochloride (MAP) in bulk drug and pharmaceutical formulations. Chromatographic separation was accomplished on a C18 column (100 x 4mm, 3 mu m) under isocratic elution with the use of a binary solution of acetonitrile and phosphate buffer at a pH of 7 (75 : 25, v/v) and a flow rate of 0.4 mL per minute at 215 nm. The linearity was excellent in the concentration range of MAP from 0.1 to 1.5 mu g/mL with a regression coefficient of 0.9996. The proposed method was validated with the respective ICH guidelines. The drug was subjected to hydrolytic, acidic, basic, thermal, photolytic, and oxidative stress conditions as required by the ICH regulation. The method was found to be suitable for use in routine practice to analyze MAP in the pharmaceutical dosage form.
dc.identifier.citationOnal C., TEKKELİ Ş. E. , -Stability-indicating ultra-fast liquid chromatographic analysis of maprotiline in pharmaceutical formulations-, JOURNAL OF CHEMICAL METROLOGY, cilt.13, ss.80-83, 2019
dc.identifier.doi10.25135/jcm.27.19.07.1349
dc.identifier.trdizinISSN: 1307-6183
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24677
dc.identifier.wosWOS:000504867300008
dc.titleStability-indicating ultra-fast liquid chromatographic analysis of maprotiline in pharmaceutical formulations
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd9b16c2d-e389-411f-9808-7c386397aeee
local.publication.isinternational1
relation.isAuthorOfPublication837d5047-762e-43db-b252-9f3d1399378f
relation.isAuthorOfPublication.latestForDiscovery837d5047-762e-43db-b252-9f3d1399378f
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