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Determining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivity

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Date
2013-07-01T00:00:00Z
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Kucukbayrak, Abdulkadir
CAKMAK, Saadet
Hakyemez, Ismail Necati
Tas, Tekin
Akdeniz, Hayrettin
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Abstract
Since the 1990s, blood donors have been scanned for anti-hepatitis C virus (anti-HCV) antibodies, which can be defined by enzyme immunoassay as a screening test. In this population, false-reactive ratios have been high. Recently, some authors have aimed to find a cutoff value for anti-HCV different from those established by test manufacturers to predict HCV infection. In this study, 321 patients, after two repeating tests, had reactive results in s/co 2.61 s/co, with 74.1 % sensitivity and 71.6 % specificity (area under the curve, 0.820; 95 % confidence interval, 0.753 to 0.887). We suggest that an effective cutoff value for anti-HCV other than that established by the manufacturer cannot be assigned to predict hepatitis C infection for blood donors in low-prevalence areas.
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Kucukbayrak A., CAKMAK S., Hakyemez I. N. , Tas T., Akdeniz H., -Determining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivity-, FOLIA MICROBIOLOGICA, cilt.58, ss.343-347, 2013
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