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Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation

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dc.contributor.authorOner, Taliha
dc.contributor.authorOzdemir, Rahmi
dc.contributor.authorDoksoz, Onder
dc.contributor.authorGenc, Dildar B.
dc.contributor.authorGuven, Baris
dc.contributor.authorDemirpence, Savas
dc.contributor.authorYilmazer, Murat M.
dc.contributor.authorYozgat, Yılmaz
dc.contributor.authorMese, Timur
dc.contributor.authorTavli, Vedide
dc.contributor.institutionauthorYOZGAT, YILMAZ
dc.date.accessioned2020-04-10T21:00:01Z
dc.date.available2020-04-10T21:00:01Z
dc.date.issued2018-07-01T00:00:00Z
dc.description.abstractBackground: Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans. Aim: We evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial. Methods: A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group. Results: Compared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation. Conclusion: In conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.
dc.identifier.citationOner T., Ozdemir R., Doksoz O., Genc D. B. , Guven B., Demirpence S., Yilmazer M. M. , Yozgat Y., Mese T., Tavli V., -Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation-, CARDIOLOGY IN THE YOUNG, cilt.28, ss.949-954, 2018
dc.identifier.doi10.1017/s1047951118000574
dc.identifier.scopus85047143236
dc.identifier.urihttps://hdl.handle.net/20.500.12645/16365
dc.identifier.wosWOS:000434245900008
dc.identifier.yoksis4700876
dc.language.isoen
dc.titleCardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation
dc.typeArticle
dspace.entity.typePublication
local.avesis.ide7c92415-dcb9-4f97-acfb-c0f7dc5f7bf3
local.publication.isinternational1
relation.isAuthorOfPublicationac2e862c-9b22-4e55-980d-263d9c5fb35a
relation.isAuthorOfPublication.latestForDiscoveryac2e862c-9b22-4e55-980d-263d9c5fb35a
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