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ACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment

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dc.contributor.authorGepdiremen, Ali Akçahan
dc.contributor.authorKumaş, Meltem
dc.contributor.institutionauthorGEPDİREMEN, ALİ AKÇAHAN
dc.date.accessioned2021-02-01T20:59:39Z
dc.date.available2021-02-01T20:59:39Z
dc.date.issued2020-12-01T00:00:00Z
dc.description.abstractSeveral repurposing drugs and ongoing vaccine researches tocombat Coronavirus Disease-19 (COVID-19) are testing clinically,worldwide. COVID-19 caused by severe acute respiratory failuresyndrome-CoV-2, uses angiotensin-converting enzyme 2 (ACE-2) as a functional receptor for entry into the cells, followed by itspriming by transmembrane protease serine 2 (TMPRSS2). Most ofthe ACE-2 expressing cells are alveolar type II pneumocytes. ViralS-glycoprotein, TMPRSS2 and ACE-2 inhibition, as extracellularmedia components, are potential targets of future therapy. ACE-2 and/or TMPRSS2 blockade is thought to be beneficial in theprevention or treating of this infection which will be the mostconvenient for pharmacoeconomics and effectiveness, regardingsimilar future pandemics. Despite substrate-based design andsynthesis of ACE-2 inhibitor compounds were presented almosttwo decades ago, data on renin angiotensin system activation orits blockers, especially ACE-2, are limited by now. Priority mustbe given to design a convenient vaccine soon, but due to the highmutation ability of such viruses mean that new vaccines may needto be developed for each outbreak. So, de novo drugs such as ACE-2or TMPRSS2 blockers need to be developed which can specificallyblock spike binding sites of the target cells and prevent virusintrusion, especially at the extracellular media, for future pandemics.
dc.identifier.citationGepdiremen A. A. , Kumaş M., -ACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment-, Bezmiâlem Science, cilt.8, ss.79-83, 2020
dc.identifier.doi10.14235/bas.galenos.2020.4756
dc.identifier.trdizin485119
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28248
dc.identifier.wosWOS:000613758900004
dc.subjectCOVID-19
dc.subjectACE-2
dc.subjectSARS-CoV-2
dc.subjectRAAS
dc.subjectTMPRSS2
dc.subjectcoronavirus
dc.titleACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7c9451ce-b134-4a14-9c38-3f200b94075a
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational0
relation.isAuthorOfPublicationdc70adc1-eb72-4820-8b6d-4b39285a568f
relation.isAuthorOfPublication.latestForDiscoverydc70adc1-eb72-4820-8b6d-4b39285a568f
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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