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Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.

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dc.contributor.authorYILDIRIM, ZEYNEP BEYZA
dc.contributor.authorSUMNU, A
dc.contributor.authorBADEMLER, N
dc.contributor.authorKILIC, ERDEM
dc.contributor.authorSUMNU, G
dc.contributor.authorKARADAG, S
dc.contributor.authorGURSU, MELTEM
dc.contributor.authorOZEL, A
dc.contributor.authorBATMAZ, G
dc.contributor.authorATES, SEDA
dc.contributor.authorDane, B
dc.contributor.authorOZTURK, S
dc.contributor.institutionauthorYILDIRIM, ZEYNEP BEYZA
dc.contributor.institutionauthorKILIÇ, ERDEM
dc.contributor.institutionauthorGÜRSU, MELTEM
dc.contributor.institutionauthorATEŞ, SEDA
dc.contributor.institutionauthorKILIÇOĞLU DANE, PAKİZER BANU
dc.date.accessioned2019-10-05T14:31:01Z
dc.date.available2019-10-05T14:31:01Z
dc.date.issued2016-01-01
dc.description.abstractntroduction: All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group. Materials and methods: The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit. Results: Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) (p = 0.04). Discussion: Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.en
dc.identifier10.1002/ajmg.c.31409
dc.identifier.citationYILDIRIM Z. B. , SUMNU A., BADEMLER N., KILIC E., SUMNU G., KARADAG S., GURSU M., OZEL A., BATMAZ G., ATES S., et al., -Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.-, Disease markers, cilt.2016, ss.5930589, 2016
dc.identifier.pubmed26989294
dc.identifier.urihttps://hdl.handle.net/20.500.12645/4102
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleSoluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameAMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
local.avesis.id6381d4d2-a815-4ef2-8f05-fb6fd517a0b9
local.avesis.response3972
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relation.isAuthorOfPublication.latestForDiscoverya6446eac-0ccd-4457-9227-3fc72dec68d1
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