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Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol

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dc.contributor.authorTodurga Seven, Zeynep Gizem
dc.contributor.authorBolkent, Sema
dc.contributor.authorKöse, Çağla
dc.contributor.authorÇoşkun, Zeynep Mine
dc.contributor.authorGökdemir, Selim
dc.contributor.authorAkkan, Ahmet Gökhan
dc.contributor.authorÖzyazgan, Sibel
dc.contributor.institutionauthorAKKAN, AHMET GÖKHAN
dc.date.accessioned2022-01-07T20:59:18Z
dc.date.available2022-01-07T20:59:18Z
dc.date.issued2021-02-01T00:00:00Z
dc.description.abstract: In recent years, cannabinoids have been shown to have beneficial effects on diabetic vascular complica tions. Vascular complications due to fructose-induced hyperinsulinemia (HI) and diabetic vascular complications have similar mechanisms. The aim of this experimental study was to observe whether the cannabinoid agonist delta-9-te trahydrocannabinol (THC) has an ameliorating effect on fructose-induced HI and vascular responses in the aortic ring of rats with HI. Methods: A total of 24 rats were categorized into 4 groups: control (standard food pellets and water), HI (water contain ing 10% fructose provided for 12 weeks), THC (1.5 mg/kg/day intraperitoneal administration for 4 weeks), and THC+HI. Body weight was measured again on the last day of the study and the serum insulin level was measured with an en zyme-linked immunosorbent assay. The acetylcholine (ACh) maximum relaxant effect in aortic rings pre-contracted with noradrenaline (NA) was evaluated. Results: The body weight of THC and THC+HI groups was lower compared with that of the controls (p<0.01). Increased insulin level as a result of fructose consumption decreased with THC administration (p<0.01) while the glucose level increased in all other groups compared with the control group (p<0.01, p<0.05). The NA Emax value decreased in the group receiving THC treatment (p<0.01). The increased ACh pD2 value in the HI groups also decreased in the THC treatment group (p<0.0001). The decreased maximum inhibition value in the HI group increased significantly with THC administration (p<0.001). Conclusion: THC demonstrated beneficial effects on fructose-induced HI. THC improved ACh-induced endothelial dependent relaxation in HI rat aortic rings. Keywords: Endothelial-dependent relaxation, hyperinsulinemia, tetrahydrocannabinol, vascular response
dc.identifier.citationTodurga Seven Z. G. , Köse Ç., Çoşkun Z. M. , Gökdemir S., Akkan A. G. , Bolkent S., Özyazgan S., -Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol-, International Journal of Medical Biochemistry, cilt.4, sa.1, ss.50-55, 2021
dc.identifier.doi10.14744/ijmb.2020.83703
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30003
dc.titleVascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9- tetrahydrocannabinol
dc.typeArticle
dspace.entity.typePublication
local.avesis.id03bd6148-df42-467c-982f-1ec6c3b69065
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational0
relation.isAuthorOfPublication3d01b102-caf1-4fba-a467-f358f2f6d3c7
relation.isAuthorOfPublication.latestForDiscovery3d01b102-caf1-4fba-a467-f358f2f6d3c7
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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