Publication:
The impact of asymptomatic kidney stones on disease progression in autosomal dominant polycystic kidney disease

dc.contributor.authorELÇİOĞLU Ö. C.
dc.contributor.authorYatci B.
dc.contributor.authorÖZTÜRK B. B.
dc.contributor.authorMİRİOĞLU Ş.
dc.contributor.authorGÜRSU M.
dc.contributor.authorKAZANCIOĞLU R.
dc.date.accessioned2025-03-25T21:50:56Z
dc.date.issued2025-02-01
dc.description.abstractBackground Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common hereditary disorder leading to end-stage kidney disease due to the progressive formation of renal cysts. Nephrolithiasis is a frequent complication of ADPKD, with a prevalence significantly higher than in the general population. However, its role in disease progression remains underexplored. This study investigates the impact of asymptomatic nephrolithiasis on kidney function decline in ADPKD patients. Methods A retrospective cohort of 195 ADPKD patients was followed at our nephrology clinic. Of these, 85 patients had nephrolithiasis (N+), and 110 did not (N-). Data on demographic characteristics, biochemical parameters, and kidney function were collected. Delta eGFR (change in eGFR over time) served as the primary outcome. Statistical analyses, including correlation and multiple linear regression, were performed to assess the predictors of Delta eGFR. Results The N + group exhibited a significantly greater decline in kidney function compared to the N- group (Delta eGFR: 16.53 vs. 12.82 mL/min/1.73 m(2), p = 0.008). Lower calcium levels were observed in the N + group (p = 0.007), potentially reflecting metabolic abnormalities linked to nephrolithiasis. Nephrolithiasis was independently associated with kidney function decline (B = 3.159, p = 0.038). Follow-up duration was strongly associated with Delta eGFR (p < 0.001). Age showed a trend toward significance but did not reach statistical significance. Conclusion Asymptomatic nephrolithiasis is associated with accelerated kidney function decline in ADPKD patients. These findings highlight the importance of monitoring kidney stones, even in the absence of symptoms, to mitigate their impact on renal dysfunction.
dc.identifier.citationELÇİOĞLU Ö. C., Yatci B., ÖZTÜRK B. B., MİRİOĞLU Ş., GÜRSU M., KAZANCIOĞLU R., "The impact of asymptomatic kidney stones on disease progression in autosomal dominant polycystic kidney disease", BMC NEPHROLOGY, sa.1, 2025
dc.identifier.doi10.1186/s12882-025-03979-7
dc.identifier.issn1471-2369
dc.identifier.issue1
dc.identifier.pubmed39994555
dc.identifier.urihttps://hdl.handle.net/20.500.12645/40492
dc.identifier.wosWOS:001429451700002
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectNephrology
dc.subjectHealth Sciences
dc.subjectÜroloji Ve Nefroloji
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (Med)
dc.subjectUrology & Nephrology
dc.subjectClinical Medicine
dc.subjectClinical Medicine (Med)
dc.subjectÜroloji
dc.subjectUrology
dc.titleThe impact of asymptomatic kidney stones on disease progression in autosomal dominant polycystic kidney disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id87fb1583-7056-468b-bfbb-1e55ba5dce8b

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