Publication: Curcumin-crosslinked single-chain polymer nanoparticles as potential polymer-drug conjugates
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Batu H. K.
Öztürk Civelek D.
Temel B.
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Abstract
Single-chain polymer nanoparticles (SCNPs) conjugated with curcumin were developed via Williamson etherification, offering a promising platform for drug delivery. Poly[(poly(ethylene glycol) methyl ether methacrylate)-r-(2-bromoethyl methacrylate)] was synthesized by reversible addition-fragmentation chain- transfer (RAFT) polymerization, with an 80:20 ratio chosen for optimal properties. Curcumin conjugation to 2-bromoethyl methacrylate (BEMA) units was confirmed through UV-Vis and NMR spectroscopy. The obtained SCNPs exhibited reduced molecular weights and hydrodynamic diameters (<7.66 nm) compared to their polymer precursors as confirmed by GPC and DLS. TEM analyses revealed that the obtained SCNPs exhibited spherical morphology. SCNP-2 exhibited pH-responsive curcumin release, with a cumulative release of 48% at pH 5.0 and 8% at pH 7.4 over 20 d. Cellular uptake studies revealed significant SCNP-2 accumulation in MDA-MB-231 cells. Cytotoxicity assays showed selective toxicity against cancer cells, while the polymer alone exhibited no cytotoxicity, highlighting its safety. These findings suggest that curcumin-conjugated SCNPs have potential as targeted cancer therapy agents.
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Kimya Mühendisliği ve Teknolojisi, Kimya, Analitik Kimya, Fizikokimya, Polimer Karakterizasyonu, Temel Bilimler, Mühendislik ve Teknoloji, Chemical Engineering and Technology, Chemistry, Analytical Chemistry, Physical Chemistry, Characterization of Polymers, Natural Sciences, Engineering and Technology, Mühendislik Bilişim Ve Teknoloji (Eng), Temel Bilimler (Sci), Mühendislik, Polimer Bilimi, Mühendislik Kimyasal, Kimya Analitik, Engineering Computing & Technology (Eng), Natural Sciences (Sci), Engineering, Polymer Science, Engineering Chemical, Chemistry Analytical, Fizik Bilimleri, Genel Kimya Mühendisliği, Polimerler ve Plastikler, Physical Sciences, General Chemical Engineering, Polymers and Plastics, chain collapse, curcumin, polymer-drug conjugates, Reversible addition-fragmentation chain-transfer polymerization, single-chain polymer nanoparticle
Citation
Batu H. K., Öztürk Civelek D., Temel B., "Curcumin-crosslinked single-chain polymer nanoparticles as potential polymer-drug conjugates", International Journal of Polymeric Materials and Polymeric Biomaterials, 2025