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Effect of tight control management on Crohn-s disease (CALM): a multicentre, randomised, controlled phase 3 trial

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dc.contributor.authorColombel, Jean-Frederic
dc.contributor.authorPanaccione, Remo
dc.contributor.authorBossuyt, Peter
dc.contributor.authorLukas, Milan
dc.contributor.authorBaert, Filip
dc.contributor.authorVanasek, Tomas
dc.contributor.authorDanalioglu, Ahmet
dc.contributor.authorNovacek, Gottfried
dc.contributor.authorArmuzzi, Alessandro
dc.contributor.authorHebuterne, Xavier
dc.contributor.authorTravis, Simon
dc.contributor.authorDanese, Silvio
dc.contributor.authorReinisch, Walter
dc.contributor.authorSandborn, William J.
dc.contributor.authorRutgeerts, Paul
dc.contributor.authorHommes, Daniel
dc.contributor.authorSchreiber, Stefan
dc.contributor.authorNeimark, Ezequiel
dc.contributor.authorHuang, Bidan
dc.contributor.authorZhou, Qian
dc.contributor.authorMendez, Paloma
dc.contributor.authorPetersson, Joel
dc.contributor.authorWallace, Kori
dc.contributor.authorRobinson, Anne M.
dc.contributor.authorThakkar, Roopal B.
dc.contributor.authorD'Haens, Geert
dc.date.accessioned2020-10-22T18:05:10Z
dc.date.available2020-10-22T18:05:10Z
dc.date.issued2017-12-01T00:00:00Z
dc.description.abstractBackground Biomarkers of intestinal inflammation, such as faecal calprotectin and C-reactive protein, have been recommended for monitoring patients with Crohn-s disease, but whether their use in treatment decisions improves outcomes is unknown. We aimed to compare endoscopic and clinical outcomes in patients with moderate to severe Crohn-s disease who were managed with a tight control algorithm, using clinical symptoms and biomarkers, versus patients managed with a clinical management algorithm.
dc.identifier.citationColombel J., Panaccione R., Bossuyt P., Lukas M., Baert F., Vanasek T., Danalioglu A., Novacek G., Armuzzi A., Hebuterne X., et al., -Effect of tight control management on Crohn-s disease (CALM): a multicentre, randomised, controlled phase 3 trial-, LANCET, cilt.390, ss.2779-2789, 2017
dc.identifier.doi10.1016/s0140-6736(17)32641-7
dc.identifier.pubmed29096949
dc.identifier.scopus85033669878
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23976
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0140673617326417
dc.identifier.wosWOS:000418669800023
dc.titleEffect of tight control management on Crohn-s disease (CALM): a multicentre, randomised, controlled phase 3 trial
dc.typeArticle
dspace.entity.typePublication
local.avesis.id74039377-8b1c-49c4-ae6f-990ab184bbff
local.publication.isinternational1
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