Publication: Effect of tight control management on Crohn-s disease (CALM): a multicentre, randomised, controlled phase 3 trial
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Colombel, Jean-Frederic
Panaccione, Remo
Bossuyt, Peter
Lukas, Milan
Baert, Filip
Vanasek, Tomas
Danalioglu, Ahmet
Novacek, Gottfried
Armuzzi, Alessandro
Hebuterne, Xavier
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Background Biomarkers of intestinal inflammation, such as faecal calprotectin and C-reactive protein, have been recommended for monitoring patients with Crohn-s disease, but whether their use in treatment decisions improves outcomes is unknown. We aimed to compare endoscopic and clinical outcomes in patients with moderate to severe Crohn-s disease who were managed with a tight control algorithm, using clinical symptoms and biomarkers, versus patients managed with a clinical management algorithm.
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Colombel J., Panaccione R., Bossuyt P., Lukas M., Baert F., Vanasek T., Danalioglu A., Novacek G., Armuzzi A., Hebuterne X., et al., -Effect of tight control management on Crohn-s disease (CALM): a multicentre, randomised, controlled phase 3 trial-, LANCET, cilt.390, ss.2779-2789, 2017