Publication: Fulminan karaciğer yetmezliği ile seyreden viral hepatitli olguların değerlendirilmesi
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KARABELA, ŞEMSI NUR
ŞENOĞLU, SEVTAP
DURDU, BÜLENT
Bakar, Mehmet
YAŞAR, KADRIYE KART
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Abstract
Background and Aims: Fulminant hepatic failure, a severe and acute
hepatic injury that manifests as a sudden impairment of hepatic synthetic functions and progresses accompanied with encephalopathy in
patients with normal hepatic functions, is most commonly caused by
viral hepatitis in Turkey. This study analyzed patients with a fulminant
clinical course of viral hepatitis followed up in our clinic. Metarial and
Methods: Patients with viral hepatitis who were diagnosed with fulminant hepatitis between 1991 and 2012 were retrospectively analyzed.
Fulminant hepatic failure that occurred within the first 8 weeks after
the onset of the first symptoms and/or failure that occurred within 2
weeks following jaundice was accepted as acute failure, whereas failure that occurred within a longer period was considered as subacute
failure. Only demographic data and outcomes of the cases monitored
between 1991 and 1997 were available. Results: Twenty-eight (58%)
patients were female and 20 were male, and the age range was 15–70
years (mean, 35.3 years). The shortest and longest symptom onset durations were 2 and 21 days, respectively (mean, 7.4 days). Acute cases
(80%) were commonly found, and the most common type of viral hepatitis was hepatitis B (39%). Eight patients were negative for hepatitis
markers, and they had not taken any drug, plant, or toxic substance
(31%); they died on the first day of hospitalization. Twelve (25%) patients with a diagnosis of fulminant hepatitis recovered by supportive
therapy. When the distribution of cases by years was analyzed, it was
observed that the number of cases significantly decreased as the years
progressed. Conclusion: Fulminant hepatitis is a difficult clinical entity
to cure and generally progresses to mortality. The mortality rate of the
disease can be reduced depending on early diagnosis and treatment
with supportive therapy, including intensive care unit treatment and
performing hepatic transplantation.
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KARABELA Ş. N. , ŞENOĞLU S., DURDU B., Bakar M., YAŞAR K. K. , -Fulminan karaciğer yetmezliği ile seyreden viral hepatitli olguların değerlendirilmesi-, Akademik Gastroenteroloji Dergisi, cilt.15, ss.41-44, 2016