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Clinical significance of glomerular C3 deposition in primary membranous nephropathy

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dc.contributor.authorOto, Özgür Akın
dc.contributor.authorDemir, Erol
dc.contributor.authorMirioğlu, Şafak
dc.contributor.authorDirim, Ahmet Burak
dc.contributor.authorÖzlük, Mesude Yasemin
dc.contributor.authorCebeci, Egemen
dc.contributor.authorBaştürk, Taner
dc.contributor.authorUçar, Ali Rıza
dc.contributor.authorSoltanova, Lala
dc.contributor.authorNuriyev, Kanan
dc.contributor.authorKılıçaslan, Işın
dc.contributor.authorYazıcı, Halil
dc.contributor.authorÇalışkan, Yaşar Kerem
dc.contributor.institutionauthorMİRİOĞLU, ŞAFAK
dc.date.accessioned2021-01-20T20:59:18Z
dc.date.available2021-01-20T20:59:18Z
dc.date.issued2021-01-01T00:00:00Z
dc.description.abstractBackground We aimed to investigate the effects of glomerular C3 deposition on clinical, histopathological features, and outcomes of patients with primary membranous nephropathy (MN). Methods A total of 261 patients with biopsy-proven primary MN, who were on follow up for at least 6 months, were included in the study. The patients were grouped according to their C3 immunostaining in kidney biopsy samples at the time of diagnosis: Low intensity [LI; (C3 1 +)] and high intensity [HI; (C3 2 + or C3 3 +)]. The primary outcome was the development of kidney failure. Complete (CR) or partial remission (PR) was defined as secondary outcome. Results Sixteen patients reached the primary outcome after a median follow-up of 33.8 months. Patients in the high intensity group (119 cases) had lower eGFR and higher proteinuria at admission and last follow-up compared to patients in the low intensity group (142 cases). Also, more patients in the high intensity group reached the primary outcome compared to patients in the low intensity group: twelve patients (10.1%) in the high intensity group and four patients (2.8%) in the low intensity group reached the primary outcome (p = 0.015). Kaplan-Meier analysis demonstrated that patients in the high intensity group had a higher risk for kidney failure (p = 0.02). In multivariate logistic regression analysis, high intensity C3 deposition and initial estimated glomerular filtration rate (eGFR) indepenently predicted primary outcome. Conclusion Extensive glomerular C3 deposition is a predictor of kidney failure in patients with MN.
dc.identifier.citationOto Ö. A. , Demir E., Mirioğlu Ş., Dirim A. B. , Özlük M. Y. , Cebeci E., Baştürk T., Uçar A. R. , Soltanova L., Nuriyev K., et al., -Clinical significance of glomerular C3 deposition in primary membranous nephropathy-, JOURNAL OF NEPHROLOGY, 2021
dc.identifier.doi10.1007/s40620-020-00915-w
dc.identifier.scopus85098737347
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28064
dc.identifier.wosWOS:000604170000003
dc.titleClinical significance of glomerular C3 deposition in primary membranous nephropathy
dc.typeArticle
dspace.entity.typePublication
local.avesis.idbdd4c8a6-4614-48ad-a5dd-af25b5eae6fb
local.publication.isinternational1
relation.isAuthorOfPublication1a6fde04-64ba-4074-8a18-b696ffbbbd3e
relation.isAuthorOfPublication.latestForDiscovery1a6fde04-64ba-4074-8a18-b696ffbbbd3e
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