Publication: Diagnostic and Prognostic Value of Pentraxin 3, Interleukin-6, CRP, and Procalcitonin Levels in Patients with Sepsis and Septic Shock
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Date
2024-03-01
Authors
Authors
Palalioǧlu B.
Erdoǧan S.
Atay G.
Tugrul H.
ÖZER Ö. F.
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Abstract
Introduction and Purpose: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. Materials and Methods: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared. Patients were compared with the age-appropriate case-control group formed from the patients who received pre-operative routines to investigate the diagnostic value. Results: CRP, IL-6, and PTX3 levels of the patients were significantly higher compared to controls (P 32 pg/mL, 88.9% sensitivity, 65.6% specifity). Conclusion: The results of this study indicated that IL-6 level is an appropriate biomarker with high specificity in the diagnosis of sepsis and septic shock and in evaluating the response to treatment and determining the prognosis.
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Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, Klinik Tıp (MED), Klinik Tıp, TIP, GENEL & DAHİLİ, Clinical Medicine (MED), CLINICAL MEDICINE, MEDICINE, GENERAL & INTERNAL, Genel Tıp, General Medicine, Critical ill patient, interleukin-6, pentraxin-3, procalcitonin, sepsis
Citation
Palalioǧlu B., Erdoǧan S., Atay G., Tugrul H., ÖZER Ö. F., "Diagnostic and Prognostic Value of Pentraxin 3, Interleukin-6, CRP, and Procalcitonin Levels in Patients with Sepsis and Septic Shock", Nigerian Journal of Clinical Practice, cilt.27, sa.3, ss.317-324, 2024