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Trade-off efficacy and data processing strategy in the power of spectral resolution of co-formulated antihypertensive pharmaceuticals

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dc.contributor.authorRostom, Yasmin
dc.contributor.authorLotfy, Hayam M.
dc.contributor.authorOzturk, Meltem
dc.contributor.authorTiris, Gizem
dc.contributor.authorERK, NEVİN
dc.contributor.authorSaleh, Sarah S.
dc.contributor.institutionauthorTIRIS, GİZEM
dc.date.accessioned2021-01-19T21:00:14Z
dc.date.available2021-01-19T21:00:14Z
dc.date.issued2021-02-01T00:00:00Z
dc.description.abstractVersatile, extraction-free univariate spectrophotometric methods have been modified to get effective spectral resolution of mixtures in accordance with their feature challenges. The proposed methods have been applied and validated for analyzing some antihypertensive medicines in their co-formulated medicinal products. Two mixtures have been used: the first one [Mix I (OLM/ADB)] is composed of Olmesartan medoxomil (OLM) and Amlodipine besylate (ADB) with partly-overlapped spectra while the second [Mix II (TEL/HCT)] is made up Telmisartan (TEL) and Hydrochlorothiazide (HCT) with total-overlapped spectra. Induced dual wavelength, absorbance correction and ratio subtraction coupled with constant multiplication methods were applied to Mix I (OLM/ADB), while dual wavelength, advanced absorbance subtraction and constant center coupled with spectrum subtraction methods were applied to Mix II (TEL/HCT). Calibration graphs were established with good correlation coefficients. The methods exhibit significant advantages as simplicity, sensitivity, minimal data manipulation besides optimum robustness. Selectivity was inspected using lab-mixtures with diverse ratios. Accuracy, precision and repeatability were found to be within the acceptable limits. The proposed methods are good enough to be used for co-assay of analytes in combined forms without any interfering from excipients. Moreover, all results were estimated in accordance with ICH criteria and successfully compared with those of the reported methods applying t-test and F-test at 95% confidence level. Generally, these methods can be used efficiently for routine quality control testing. (C) 2020 Elsevier B.V. All rights reserved.
dc.identifier.citationRostom Y., Lotfy H. M. , Ozturk M., Tiris G., ERK N., Saleh S. S. , -Trade-off efficacy and data processing strategy in the power of spectral resolution of co-formulated antihypertensive pharmaceuticals-, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.247, 2021
dc.identifier.doi10.1016/j.saa.2020.119080
dc.identifier.pubmed33126135
dc.identifier.scopus85094319246
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28031
dc.identifier.wosWOS:000601062500004
dc.titleTrade-off efficacy and data processing strategy in the power of spectral resolution of co-formulated antihypertensive pharmaceuticals
dc.typeArticle
dspace.entity.typePublication
local.avesis.idb7f8878c-338a-4de0-9fd2-117378971b0e
local.publication.isinternational1
relation.isAuthorOfPublication1ab47475-d54a-4b46-a679-47fb775bc1ce
relation.isAuthorOfPublication.latestForDiscovery1ab47475-d54a-4b46-a679-47fb775bc1ce
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