Publication:
Serum chitotriosidase activity: is it a new inflammatory marker in obese children?

Simple item page
dc.contributor.authorKUNDAK, Ahmet Afsin
dc.contributor.authorTASCILAR, Mehmet Emre
dc.contributor.authorABACI, Ayhan
dc.contributor.authorDEVRIM, Ilker
dc.contributor.authorOzgen, Ilker Tolga
dc.contributor.authorDEMIRTEK, Ugur
dc.contributor.authorOZTURK, Ozlem
dc.contributor.authorOLGUN, Abdullah
dc.contributor.authorKURT, Ismail
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.date.accessioned2020-10-29T20:26:44Z
dc.date.available2020-10-29T20:26:44Z
dc.date.issued2012-02-01T00:00:00Z
dc.description.abstractChitotriosidase (ChT) is an enzyme secreted by activated macrophages and involved in defense against, and in degradation of chitin-containing pathogens, such as fungi, nematodes, and insects. In addition, it plays an important role in the development of atherosclerosis related with systemic low-grade inflammation. To this effect of activity of ChT, we aimed to investigate serum ChT activity in obese subjects and to determine to relation with insulin resistance and high-sensitive C-reactive protein (hsCRP). A total of 73 obese subjects (10.9+/-2.6 years of age, 44 male patients) and 41 age and gender-matched healthy lean subjects (11.6+/-2.9 years of age, 18 male patients) were included in this study, between 2007 and 2008. The criterion for diagnosing obesity was defined as the body mass index (BMI) being over 97th percentile of the same gender and age. Fasting serum glucose, insulin, hsCRP and ChT levels were measured. We compared the differences in variables between obese and lean subjects with Student-s t-test compared after ascertaining that the data were normally distributed. All data were expressed as mean+/-standard deviation. There was statistically significant increase in serum ChT activity of obese subjects, while there was statistically significant difference in serum hsCRP levels when compared to healthy lean subjects (30.0+/-17.9 and 23.0+/-17.8, p = 0.045; 2.3+/-3.1 and 0.7+/-1.2, p = 0.001). Obese subjects had significantly higher BMI-SDS, TG and HOMA-IR and lower HDL-C levels when compared with the healthy lean subjects (p 0.05). Although the data need to be validated by further investigation, the observations made in this study seem to indicate that serum ChT activity may not be a useful marker for monitoring systemic low-grade inflammation and insulin resistance in obese subjects.
dc.identifier.citationKUNDAK A. A. , TASCILAR M. E. , ABACI A., DEVRIM I., Ozgen I. T. , DEMIRTEK U., OZTURK O., OLGUN A., KURT I., -Serum chitotriosidase activity: is it a new inflammatory marker in obese children?-, JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.25, ss.63-67, 2012
dc.identifier.doi10.1515/jpem.2011.329
dc.identifier.scopus84858273536
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26047
dc.identifier.wosWOS:000305708000009
dc.titleSerum chitotriosidase activity: is it a new inflammatory marker in obese children?
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6a210847-a1c0-46f5-a0ce-30a2494fa8b5
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublicationc6ad9225-905e-4761-8da0-36efba996f82
relation.isAuthorOfPublication.latestForDiscoveryc6ad9225-905e-4761-8da0-36efba996f82
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Collections
Silinecekler