Publication: Botulinum toxin A for the treatment of strabismus in children with neurological impairment Toxına botulínica tipo A para o tratamento de estrabısmo em crianças neurologicamente comprometidas
No Thumbnail Available
Date
2023-01-01
Authors
Authors
TUĞCU B.
Araz-Ersan B.
Özkan S. B.
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
Purposes: To assess the efficacy of botulinum toxin A injection in the treatment of strabismus in patients with neurological impairment and evaluate the factors associated with treatment success. Methods: The study included 50 patients with strabismus and neurological impairment. In all children, botulinum toxin injection was performed into the appropriate extraocular muscle. The relationship between demographic features, clinical characteristics, and treatment success were analyzed. Results: In the study group, 34 patients had esotropia, and 16 patients had exotropia. As neurological problems, 36 patients had cerebral palsy, and 14 had hydrocephalus. The average follow-up period was 15.3 ± 7.3 months. The mean number of injections was 1.4 ± 0.6. The mean angle of deviation was 42.5 ± 13.2 PD before the treatment, which decreased to 12.8 ± 11.9 PD after the treatment. Successful motor alignment (orthotropia within 10 PD) was achieved in 60% of the patients. Binary logistic regression analysis revealed that esotropic misalignment and shorter duration of strabismus was significantly associated with treatment success in the study group. Patients with esotropia and lower angles of misalignment were more likely to be treated with a single injection. Conclusion: The use of botulinum toxin A for the treatment of strabismus in children with neurological impairment is a good alternative to conventional surgical therapy with a lower risk of over-correction. The treatment outcome is better in esodeviations and shorter duration of strabismus, implying an advantage of early treatment.
Description
Keywords
Tıp, Cerrahi Tıp Bilimleri, Göz Hastalıkları ve Cerrahisi, Sağlık Bilimleri, Medicine, Surgery Medicine Sciences, Eye Diseases and Surgery, Health Sciences, Klinik Tıp (MED), Klinik Tıp, GÖZ HASTALIKLARI, Clinical Medicine (MED), CLINICAL MEDICINE, OPHTHALMOLOGY, Oftalmoloji, Ophthalmology, Botulinum toxin, Cerebral palsy, Children, Hydrocephalus, Nervous system diseases, Neurological manifestations, Strabismus
Citation
TUĞCU B., Araz-Ersan B., Özkan S. B., "Botulinum toxin A for the treatment of strabismus in children with neurological impairment Toxına botulínica tipo A para o tratamento de estrabısmo em crianças neurologicamente comprometidas", Arquivos Brasileiros de Oftalmologia, cilt.87, sa.4, 2023