Publication: Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
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2014-03-01T00:00:00Z
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ÇOPUR ÇİÇEK, AYŞEGÜL
Duzgun, Azer Ozad
Bonnin, Remy A.
Ceylan, Aysenur
Saral, Aysegul
Nordmann, Patrice
Sandalli, Cemal
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Abstract
Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.
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Iraz M., Duzgun A. O. , ÇOPUR ÇİÇEK A., Bonnin R. A. , Ceylan A., Saral A., Nordmann P., Sandalli C., -Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey-, DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, cilt.78, ss.292-294, 2014