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Evaluation of concentrations of pro/anti-inflammatory cytokines after complication-free ECRP in cholangiocarcinoma

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dc.contributor.authorYILDIZ, Kemal
dc.contributor.authorInce, ALİ TÜZÜN
dc.contributor.authorGANGARAPU, Venkatanarayana
dc.contributor.authorBUGDACI, Mehmet Sait
dc.contributor.authorBAYSAL, Birol
dc.contributor.authorKAYAR, Yusuf
dc.contributor.authorKemik, Ahu Sarbay
dc.contributor.authorSenturk, HAKAN
dc.contributor.institutionauthorİNCE, ALİ TÜZÜN
dc.contributor.institutionauthorŞENTÜRK, HAKAN
dc.date.accessioned2019-10-05T13:16:28Z
dc.date.available2019-10-05T13:16:28Z
dc.date.issued2014-12-01
dc.description.abstractBackground/Aims: Variations in pro and anti-inflammatory cytokine levels occur commonly after ERCP procedure complications, such as in post-ERCP pancreatitis. Besides, the relationship between increased cytokine levels and multidrug resistance has been shown in cholangiocarcinoma patients. Our aim was to investigate the impact of cytokine level changes on treatment strategy after uncomplicated ERCP procedures in cholangiocarcinoma patients. Materials and Methods: Of 75 patients enrolled in this study, 25 were cholangiocarcinoma, and 50 were choledocholithiasis patients. Levels of serum IL-1β, IL-6, IL-8, IL-10, and TNF-α were evaluated 2 hours before and 12 hours after complication-free ERCP, and statistical analysis of the results was obtained; if p value <0.05, it was accepted as statistically significant. Results: There was no statistically significant difference in the distribution of age (23-87 years; range: 59.8±16.6), gender (37 males vs 38 females), and levels of pre- and post-ERCP serum IL-1β, IL-6, IL-8, IL-10, and TNF-α in both patient groups, despite the presence of some change in test means (p:0.179, 0.445, 0.522, 0.937, and 0.065, respectively). However, significantly decreased levels of TNF-α were observed in the benign group, when comparing pre- and post-ERCP period (p<0.05). Conclusion: Serum concentrations of IL-1β, IL-6, IL-8, IL-10, and TNF-α evaluated after complication-free ERCP performed in patients with cholangiocarcinoma do not cause any change in treatment planning that would affect multidrug resistanceen
dc.identifier10.1016/j.bjoms.2012.08.003
dc.identifier.citationYILDIZ K., Ince A. T. , GANGARAPU V., BUGDACI M. S. , BAYSAL B., KAYAR Y., Kemik A. S. , Senturk H., -Evaluation of concentrations of pro/anti-inflammatory cytokines after complication-free ECRP in cholangiocarcinoma-, TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.25, ss.133-137, 2014
dc.identifier.doi10.5152/tjg.2014.6762
dc.identifier.pubmed25910291
dc.identifier.scopus84952715412
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1797
dc.identifier.wosWOS:000353553700025
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEvaluation of concentrations of pro/anti-inflammatory cytokines after complication-free ECRP in cholangiocarcinoma
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameThe British journal of oral &amp; maxillofacial surgery
local.avesis.id2aec9669-2d25-4630-b2ba-d766b0baf45b
local.avesis.response1667
local.publication.isinternational1
relation.isAuthorOfPublication6daa6ab7-ee45-4f50-9e71-e831046b6462
relation.isAuthorOfPublication278fcf63-3b92-4368-bff6-f140ebd9aeb3
relation.isAuthorOfPublication.latestForDiscovery278fcf63-3b92-4368-bff6-f140ebd9aeb3
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