Publication: Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study.
dc.contributor.author | Dinç, HARİKA ÖYKÜ | |
dc.contributor.author | Demirci, Mehmet | |
dc.contributor.author | Özdemir, Yusuf Emre | |
dc.contributor.author | Sirekbasan, Serhat | |
dc.contributor.author | Aktaş, Ayse Nur | |
dc.contributor.author | Karaali, Rıdvan | |
dc.contributor.author | Tuyji Tok, Yeşim | |
dc.contributor.author | Özbey, Doğukan | |
dc.contributor.author | Akçin, Rüveyda | |
dc.contributor.author | Gareayaghi, Nesrin | |
dc.contributor.author | Kuşkucu, Mert Ahmet | |
dc.contributor.author | Midilli, Kenan | |
dc.contributor.author | Aygün, Gökhan | |
dc.contributor.author | Sarıbaş, Suat | |
dc.contributor.author | Kocazeybek, Bekir | |
dc.contributor.institutionauthor | DİNÇ, HARİKA ÖYKÜ | |
dc.date.accessioned | 2022-05-05T20:59:20Z | |
dc.date.available | 2022-05-05T20:59:20Z | |
dc.date.issued | 2022-04-05T00:00:00Z | |
dc.description.abstract | Background: Monitoring the longevity of immunoglobulin G (IgG) responses following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections is vital to understanding the role of antibodies in preventing infection. Aims: To determine the quantitative IgG responses specific to the Spike-S1 (S1) receptor-binding domain (S1/RBD) region of the virus in serum samples taken between 4 weeks and 7 months after polymerase chain reaction (PCR) positivity in patients who are diagnosed with coronavirus disease-2019 (COVID-19). Study design: A longitudinal study. Methods: This study included 113 patients with a clinical and molecular diagnosis of COVID-19. The first and second serum samples were taken 1 and 7 months, respectively, after the PCR positivity. S1/RBD-specific IgG antibody response was assayed using anti-SARS-CoV- 2 QuantiVac ELISA (IgG) kit (Euroimmun, Lübeck, Germany). The neutralizing antibodies were investigated in 57 patients whose IgG test results were above the cut-off value. Results: In 57 patients with SARS-CoV-2 IgG, the anti-SARS-CoV-2 IgG quantitative antibody levels significantly decreased after 7 months (Z = −2.197, p = 0.028). A correlation was detected between the anti-SARS-CoV-2 IgG and nAb percent inhibition (IH%) levels detected in 1 month (rs = 0.496, p < 0.001), but without significant correlation in serum samples taken on 7 months. The nAb IH% levels of the first and second were compared for COVID-19 severity and revealed no statistical difference (p = 0.256). In the second serum sample, the nAb IH%s of patients with moderate COVID-19 showed a statistically significant difference from patients with mild COVID-19 (p = 0.018), but without significant differences between severe and moderate or mild COVID-19. Conclusion: SARS-CoV-2 quantitative IgG antibody titers are significantly reduced at long-term follow-up (> 6 months). Due to the limited information on seroconversion, comprehensive studies should be conducted for long-term follow-up of the immune response against SARS-CoV-2. | |
dc.identifier.doi | 10.4274/balkanmedj.galenos.2022.2021-8-131 | |
dc.identifier.pubmed | 35378574 | |
dc.identifier.scopus | 85131018883 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/30570 | |
dc.identifier.wos | WOS:000806079300002 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | COVID-19 | |
dc.subject | SARS-CoV-2 | |
dc.subject | Neutralizing antibody | |
dc.title | Anti-SARS-CoV-2 IgG and Neutralizing Antibody Levels in Patients with Past COVID-19 Infection: A Longitudinal Study. | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | ea64c9e0-fdae-49e8-8efc-9f9a0cfe4504 | |
local.indexed.at | PubMed | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 6f44fd83-f5fa-4152-9576-c7c1d7ce6ad1 | |
relation.isAuthorOfPublication.latestForDiscovery | 6f44fd83-f5fa-4152-9576-c7c1d7ce6ad1 |
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