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The microbiology of acute cholangitis and associated in-hospital mortality

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dc.contributor.authorBiberci Keskin, Elmas
dc.contributor.authorOkay, Gülay
dc.contributor.institutionauthorBİBERCİ KESKİN, ELMAS
dc.contributor.institutionauthorOKAY, GÜLAY
dc.date.accessioned2021-09-27T20:59:09Z
dc.date.available2021-09-27T20:59:09Z
dc.date.issued2021-08-01T00:00:00Z
dc.description.abstractAim:Acute cholangitis is an infection that may become life-threatening. In this study, we investigated the most prevalent organisms identified in cultures, antibiotic resistance patterns and associated in-hospital mortality.Materials and Methods:Patients diagnosed as having acute cholangitis were included in the study retrospectively. The study patients were classified in two groups by culture results as culture-negative or culture-positive patients. The aim of the study was to identify offending organisms, antibiotic resistance and in-hospital mortality based on culture results.Results:Overall, 108 patients with acute cholangitis were evaluated in two groups. Sixty six patients (61.2%) had positive cultures and 43 (40%) of these patients had polymicrobial culture results. There was a predominance of gram-negative bacteria (63%) and particularly, Klebsiella spp. and E.coli were the most commonly isolated organisms. The patients who died had 90.9% positive cultures, whereas those who survived had 53.6% culture positivity (p=0.02)Conclusions:Biliary stent implantaiton was found to be the most common etiological factor for acute cholangitis. In terms of culture results, K. pneumoniae and E. coli were the most commonly isolated causative agents. ESBL resistance was found with a rate of 48.5% and carbapenem resistance was found with a rate of 22% for gram negative bacilli. Culture positivity was a risk factor in terms of in-hospital death.
dc.identifier.citationBiberci Keskin E., Okay G., -The microbiology of acute cholangitis and associated in-hospital mortality-, Annals of Medical Research , cilt.28, sa.8, ss.1430-1434, 2021
dc.identifier.doi10.5455/annalsmedres.2020.05.516
dc.identifier.trdizinDOI: https://doi.org/10.5455/annalsmedres.2020.05.516
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/29526
dc.titleThe microbiology of acute cholangitis and associated in-hospital mortality
dc.typeArticle
dspace.entity.typePublication
local.avesis.idf6d3f013-0068-4615-aaaf-c85790ce48c0
local.publication.isinternational1
relation.isAuthorOfPublication970f9eb4-1be0-4bd2-ba93-371a0049b85b
relation.isAuthorOfPublication279981fb-cbc1-47b0-aba0-2735e8c96c27
relation.isAuthorOfPublication.latestForDiscovery279981fb-cbc1-47b0-aba0-2735e8c96c27
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