Publication: The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
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HALAC, Gulistan
SEZER, Gulsen M.
SAGLAM, Neslihan O.
Tekturk, Pinar
DEMIR, Aysegul D.
DEMIR, Saliha
AKCAY, Faruk
USLU, Aysegul
Yapici, Zuhal
Asil, TALİP
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Abstract
Objective: To examine the incidence of restless
legs syndrome (RLS) among children with iron
deficiency, or iron deficiency anemia, or both, and
the relationship between RLS prevalence and serum
ferritin levels.
Methods: This prospective, cross-sectional, case
controlled study was carried out between January and
June 2013, and included 98 iron deficiency and/or
Neurosciences 2015; Vol. 20 (4)
iron deficiency anemia, and 102 healthy children
referred to the Neurology and Pediatric Departments
of the Medical Faculty of Bezmialem Vakif University,
Istanbul, Turkey. Both groups were evaluated
according to the International Restless Legs Syndrome
Study Group diagnostic criteria.
Results: The range of ferritin levels was 0.01-12 mg/
ml in patients while it was 12.3-91.8 mg/mL in the
control group. Restless legs syndrome was detected
in 61.2% of children with iron deficiency anemia,
and in 37.3% of children with normal biochemistry
values. A statistically significant correlation was
found between serum ferritin levels and frequency
of RLS. In patients with serum ferritin levels higher
than 50 ng/ml, 92.3% had no RLS, while 55.2% of
patients with serum ferritin levels lower than 50ng/
ml had RLS. The patients with serum ferritin levels
of >50ng/ml had a significantly higher incidence of
RLS. Serum ferritin levels were significantly different
between the 2 groups.
Conclusion: The incidence of RLS, also known
as Willis-Ekbom Disease, is high in children aged
between 8-18 years with iron deficiency, or iron
deficiency anemia, or both. This finding supports the
importance of iron replacement therapy especially
during the growth and development of children.
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Citation
HALAC G., SEZER G. M. , SAGLAM N. O. , Tekturk P., DEMIR A. D. , DEMIR S., AKCAY F., USLU A., Yapici Z., Asil T., -The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey-, NEUROSCIENCES, cilt.20, ss.336-340, 2015