Publication:
Targeting Glioblastoma: The Current State of Different Therapeutic Approaches.

Simple item page
dc.contributor.authorKhan, Imran
dc.contributor.authorElbasan, Elif Burce
dc.contributor.authorMahfooz, Sadaf
dc.contributor.authorKaracam, Busra
dc.contributor.authorOztanir, MUSTAFA NAMIK
dc.contributor.authorHatiboglu, Mustafa Aziz
dc.contributor.institutionauthorKHAN, IMRAN
dc.contributor.institutionauthorELBASAN, ELİF BURÇE
dc.contributor.institutionauthorKARAÇAM, BÜŞRA
dc.contributor.institutionauthorÖZTANIR, MUSTAFA NAMIK
dc.contributor.institutionauthorHATİBOĞLU, MUSTAFA AZİZ
dc.date.accessioned2021-01-27T20:59:20Z
dc.date.available2021-01-27T20:59:20Z
dc.date.issued2021-01-13T00:00:00Z
dc.description.abstractBackground: Glioma is the primary cancer of the central nervous system in adults. Among gliomas, glioblastoma is the most deadly and aggressive form, with an average life span of 1 to 2 years. Despite implementing the rigorous standard care involving maximal surgical removal followed by concomitant radiation and chemotherapy, the patient prognosis remains poor. Due to the infiltrative nature of glioblastoma, chemo- and radio-resistance behavior of these tumors and lack of potent chemotherapeutic drugs, treatment of glioblastoma is still a big challenge. Objective: The goal of the present review is to shed some light on the present state of novel strategies, including molecular therapies, immunotherapies, nanotechnology and combination therapies for patients with glioblastoma. Methods: Peer-reviewed literature was retrieved via Embase, Ovid, PubMed and Google Scholar till the year 2020. Conclusion: Insufficient effect of chemotherapies for glioblastoma is more likely because of different drug resistance mechanisms and intrinsically complex pathological characteristics. Therefore, more advancement in various therapeutic approaches such as antitumor immune response, targeting growth regulatory and drug resistance pathways, enhancing drug delivery and drug carrier systems are required in order to establish an effective treatment approach for patients with glioblastoma.
dc.identifier.doi10.2174/1570159x19666210113152108
dc.identifier.pubmed33441071
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28188
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlioblastoma
dc.subjectimmunotherapy
dc.subjectmicroRNA
dc.subjectnano-therapy
dc.subjecttargeted therapy
dc.subjectviral therapy
dc.titleTargeting Glioblastoma: The Current State of Different Therapeutic Approaches.
dc.typeArticle
dspace.entity.typePublication
local.avesis.id81f69df1-b968-4859-b8e2-51e308de61d5
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication096be806-cf26-4766-b5b4-26f30c593af2
relation.isAuthorOfPublication934bf88b-776a-479e-a862-d93ab12d7d12
relation.isAuthorOfPublicationd3d05fbe-71f5-48e6-9cf3-31a0c97e76f9
relation.isAuthorOfPublicationae4f7327-851c-4ef2-94a7-789ed77869a8
relation.isAuthorOfPublicationdb1f8830-0234-4e6a-8b53-c1176e6da242
relation.isAuthorOfPublication.latestForDiscoveryae4f7327-851c-4ef2-94a7-789ed77869a8
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Targeting Glioblastoma The Current State of Different Therapeutic.pdf
Size:
1.06 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Yayınlar - Eserler