Publication:
Plasma growth arrest-specific 6 levels in term and preterm newborns

dc.contributor.authorAlp, Emel Eksi
dc.contributor.authorAltinkaya, Nuvit
dc.contributor.authorCagman, Zeynep
dc.contributor.authorUras, Fikriye
dc.contributor.institutionauthorÇAĞMAN, ZEYNEP
dc.date.accessioned2020-10-22T20:19:07Z
dc.date.available2020-10-22T20:19:07Z
dc.date.issued2018-01-01T00:00:00Z
dc.description.abstractObjective: Growth Arrest-Specific 6 (GAS6) is a vitamin K-dependent protein. Despite a similar structure to Protein S, it has no anticoagulant activity. An association between GAS6 and some diseases for adults has been reported. In the absence of prospective clinical studies of GAS6 in neonates, so far, the objective of this study is to obtain, for the first time, plasma GAS6 levels before and after vitamin K1 prophylaxis in full-term and pre-term newborns.Methods: 80 newborns (40 term and 40 preterm) were recruited for this study. Cord blood samples and peripheral blood samples 48h after vitamin K1 injection were collected into EDTA-tubes. GAS6 levels were measured in platelet-poor plasma by ELISA.Results: Cord blood plasma GAS6 levels in preterm and term newborns were 9.075.30ng/mL and 9.75 +/- 4.34ng/mL, respectively. In response to vitamin K1 injection, GAS6 levels increased in preterm newborns (10.50 +/- 5.28ng/mL) (p.05).Conclusion: This pilot study provided, to the best of our knowledge, the first report that GAS6 levels increased significantly after vitamin K1 prophylaxis in preterm newborns but not in term infants. This study may serve as a first step toward more extensive studies in neonates.
dc.identifier.citationAlp E. E. , Altinkaya N., Cagman Z., Uras F., -Plasma growth arrest-specific 6 levels in term and preterm newborns-, JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.31, ss.1151-1155, 2018
dc.identifier.doi10.1080/14767058.2017.1311311
dc.identifier.scopus85017410277
dc.identifier.urihttp://hdl.handle.net/20.500.12645/24652
dc.identifier.wosWOS:000427919300007
dc.titlePlasma growth arrest-specific 6 levels in term and preterm newborns
dc.typeArticle
dspace.entity.typePublication
local.avesis.idd644e22c-f40a-453e-a6a9-b4968ae91da6
local.publication.isinternational1
relation.isAuthorOfPublication7d0efdce-1dc6-4c7e-89f1-e8f96636efc0
relation.isAuthorOfPublication.latestForDiscovery7d0efdce-1dc6-4c7e-89f1-e8f96636efc0
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