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Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

dc.contributor.authorALARÇİN, EMİNE
dc.contributor.authorOzturk, Ayca Bal
dc.contributor.authorOguz, Nesrin
dc.contributor.authorEMİK, Serkan
dc.contributor.authorSahin, Hande Tekarslan
dc.contributor.institutionauthorTEKARSLAN ŞAHİN, ŞEYMA HANDE
dc.date.accessioned2020-10-21T20:20:48Z
dc.date.available2020-10-21T20:20:48Z
dc.date.issued2020-01-01T00:00:00Z
dc.description.abstractAn amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, H-1 NMR, C-13 NMR, and GPC analysis. Monodisperse HPAE-PCL-b-MPEG nanoparticles with dimensions of <200 nm and polydispersity index of <0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCL-b-MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCL-b-MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier.citationOzturk A. B. , Oguz N., Sahin H. T. , EMİK S., ALARÇİN E., -Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery-, TURKISH JOURNAL OF CHEMISTRY, cilt.44, ss.518-534, 2020
dc.identifier.doi10.3906/kim-1910-35
dc.identifier.pubmed33488174
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23400
dc.identifier.wosWOS:000522796000019
dc.titleDesign of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery
dc.typeArticle
dspace.entity.typePublication
local.avesis.id11e29214-acf7-474d-9173-d6af0e537f5f
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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