Publication:
Investigation of cardiomyopathy in children with cirrhotic and noncirrhotic portal hypertension.

dc.contributor.authorCeltik, Coskun
dc.contributor.authorDurmaz, Ozlem
dc.contributor.authorOner, Naci
dc.contributor.authorYavuz, Taner
dc.contributor.authorGökce, Selim
dc.contributor.authorAydogan, Aysen
dc.contributor.authorNisli, Kemal
dc.contributor.authorEmiroglu, H Haldun
dc.contributor.authorÖmeroglu, Rukiye E
dc.contributor.authorSökücü, Semra
dc.date.accessioned2023-05-16T16:40:05Z
dc.date.available2023-05-16T16:40:05Z
dc.date.issued2015-01-31T22:00:00Z
dc.description.abstractCirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This disorder is a well-defined entity in adults, but pediatric data are limited. The aim of the study was to determine the incidence, features, and risk factors of CCMP in children with portal hypertension (PHT).
dc.description.abstractThis study included 50 children with cirrhotic PHT (40/50) and noncirrhotic PHT (10/50). Fifty healthy children were also selected for the control group. Electrocardiography and echocardiography were used to evaluate cardiac functions. Corrected QT (QTc) ≥ 0.45 was accepted as prolonged on electrocardiography. The study group was divided into 3 groups: cirrhotic, noncirrhotic, and control. Then, the CCMP group was created according to the diagnostic criteria. Latent CCMP was diagnosed in the presence of prolonged-QTc along with a minor criterion (tachycardia). Manifest CCMP was diagnosed in the presence of at least 2 major criteria (prolonged-QTc along with abnormal echocardiographic findings). Moreover, in this study, the risk factors for CCMP were investigated.
dc.description.abstractThe CCMP group included 10 cases (20%). Nine of these cases had latent CCMP (18%), and the remaining one (2%) had manifest CCMP. All of the cases with CCMP had cirrhosis and ascites. None of the patients with CCMP had severe cardiac symptoms, but they were already using some cardioprotective drugs such as propanolol and spironolactone. As risk factors for CCMP, pediatric end-stage liver disease scores, Child-Pugh scores, and ascites grades were found to be significant for the determination of CCMP. The most important risk factor was ascites severity (P = 0.001, odds ratio 9.4).
dc.description.abstractApproximately 20% of children with PHT have CCMP. A detailed cardiac examination should be carried out periodically in children with cirrhotic PHT, especially in the presence of ascites and high Child-Pugh score.
dc.identifier.pubmed25250684
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38194
dc.language.isoen
dc.titleInvestigation of cardiomyopathy in children with cirrhotic and noncirrhotic portal hypertension.
dspace.entity.typePublication
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