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Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice

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dc.contributor.authorSakul, Arzu
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorELİBOL, BİRSEN
dc.contributor.authorAyla, Sule
dc.contributor.authorGunal, Mehmet Yalcin
dc.contributor.authorYozgat, Yasemin
dc.contributor.authorBasaga, Huveyda
dc.contributor.authorSahin, Kazim
dc.contributor.authorKAZANCIOĞLU, RÜMEYZA
dc.contributor.authorKilic, Ulkan
dc.contributor.institutionauthorELİBOL, BİRSEN
dc.contributor.institutionauthorKAZANCIOĞLU, RÜMEYZA
dc.date.accessioned2019-10-05T13:08:07Z
dc.date.available2019-10-05T13:08:07Z
dc.date.issued2019-01-01
dc.description.abstractThe clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-γ) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney through activation of AKT/mTOR signaling pathway by regulating the balance of the redox system due to its antioxidative effect.en
dc.identifier10.1159/000104876
dc.identifier.citationSakul A., Ozansoy M., ELİBOL B., Ayla S., Gunal M. Y. , Yozgat Y., Basaga H., Sahin K., KAZANCIOĞLU R., Kilic U., -Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice-, TURKISH JOURNAL OF BIOLOGY, cilt.43, ss.179-188, 2019
dc.identifier.doi10.3906/biy-1902-77
dc.identifier.pubmed31320816
dc.identifier.trdizintrdizin
dc.identifier.urihttps://hdl.handle.net/20.500.12645/1400
dc.identifier.wosWOS:000471268100003
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleSqualene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
dc.typeArticle
dspace.entity.typePublication
local.article.journalnamePHARMACOLOGY
local.avesis.id21291c54-f1a9-46bb-a265-0b1d761aa0ee
local.avesis.response1270
local.publication.isinternational1
relation.isAuthorOfPublication1b1887fb-6b32-44b1-9d9f-416616dc6734
relation.isAuthorOfPublicationeca7bd30-6b6e-444d-96ae-2961c39f2107
relation.isAuthorOfPublication.latestForDiscoveryeca7bd30-6b6e-444d-96ae-2961c39f2107
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