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Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase

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dc.contributor.authorTÜRKDOĞAN, DİLŞAD
dc.contributor.authorOrengul, ABDURRAHMAN CAHİD
dc.contributor.authorZAİMOĞLU, SENNUR
dc.contributor.authorEKİNCİ, GAZANFER
dc.contributor.institutionauthorÖRENGÜL, ABDURRAHMAN CAHİD
dc.date.accessioned2020-10-29T20:28:28Z
dc.date.available2020-10-29T20:28:28Z
dc.date.issued2014-05-01T00:00:00Z
dc.description.abstractAnti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is an autoimmune/paraneoplastic encephalitis, with neurologic and psychiatric symptoms. Early and aggressive therapy has been shown to improve prognosis although problems with executive functions and memory have continued for several years. A 15-year-old girl had a history of initial symptoms including behavioral difficulties, poor attention, and frequent seizures progressing to a catatonia-like state, 2.5 months after onset of initial symptoms. Anti-NMDA receptor antibodies were detected in serum and cerebrospinal fluid. Subsequent to treatment with methylprednisolone starting 3 months after onset, motor skills, responsiveness, self-care, and speech improved rapidly. Her neuropsychologica profile assessed after 2 months showed global difficulties predominantly in attention, executive functions, memory, and visual perception, which moderately recovered in the 7th and 24th months, respectively. Contrary to current literature supporting the positive impact of early immunomodulatory therapy, a dramatic resolution of major neurologic and psychiatric symptoms was detected with steroid treatment given in the late phase.
dc.identifier.citationTÜRKDOĞAN D., Orengul A. C. , ZAİMOĞLU S., EKİNCİ G., -Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase-, JOURNAL OF CHILD NEUROLOGY, cilt.29, ss.684-687, 2014
dc.identifier.doi10.1177/0883073813520497
dc.identifier.scopus84899695392
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26062
dc.identifier.wosWOS:000335090400016
dc.titleAnti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase
dc.typeArticle
dspace.entity.typePublication
local.avesis.id6bba815e-04f7-4ad9-be92-5e2116b26667
local.publication.isinternational1
relation.isAuthorOfPublication638c3f82-25d1-4f04-b19d-1c936d98f43d
relation.isAuthorOfPublication.latestForDiscovery638c3f82-25d1-4f04-b19d-1c936d98f43d
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