Publication: Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase
No Thumbnail Available
Date
2014-05-01T00:00:00Z
Authors
Authors
TÜRKDOĞAN, DİLŞAD
Orengul, ABDURRAHMAN CAHİD
ZAİMOĞLU, SENNUR
EKİNCİ, GAZANFER
Journal Title
Journal ISSN
Volume Title
Publisher
Metrics
Abstract
Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is an autoimmune/paraneoplastic encephalitis, with neurologic and psychiatric symptoms. Early and aggressive therapy has been shown to improve prognosis although problems with executive functions and memory have continued for several years. A 15-year-old girl had a history of initial symptoms including behavioral difficulties, poor attention, and frequent seizures progressing to a catatonia-like state, 2.5 months after onset of initial symptoms. Anti-NMDA receptor antibodies were detected in serum and cerebrospinal fluid. Subsequent to treatment with methylprednisolone starting 3 months after onset, motor skills, responsiveness, self-care, and speech improved rapidly. Her neuropsychologica profile assessed after 2 months showed global difficulties predominantly in attention, executive functions, memory, and visual perception, which moderately recovered in the 7th and 24th months, respectively. Contrary to current literature supporting the positive impact of early immunomodulatory therapy, a dramatic resolution of major neurologic and psychiatric symptoms was detected with steroid treatment given in the late phase.
Description
Keywords
Citation
TÜRKDOĞAN D., Orengul A. C. , ZAİMOĞLU S., EKİNCİ G., -Anti-N-Methyl-d-Aspartate (Anti-NMDA) Receptor Encephalitis Rapid and Sustained Clinical Improvement With Steroid Therapy Starting in the Late Phase-, JOURNAL OF CHILD NEUROLOGY, cilt.29, ss.684-687, 2014