Publication: Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study
dc.contributor.author | SÜMBÜL, BİLGE | |
dc.contributor.author | Sumbul, Hilmi Erdem | |
dc.contributor.author | OKYAY, RAMAZAN AZİM | |
dc.contributor.author | Gulumsek, Erdinc | |
dc.contributor.author | ŞAHİN, AHMET RIZA | |
dc.contributor.author | Boral, Baris | |
dc.contributor.author | Kocyigit, Burhan Fatih | |
dc.contributor.author | Alfishawy, Mostafa | |
dc.contributor.author | Gold, Jeffrey | |
dc.contributor.author | Tasdogan, Ali Muhittin | |
dc.contributor.institutionauthor | SÜMBÜL, BİLGE | |
dc.date.accessioned | 2021-03-16T20:59:20Z | |
dc.date.available | 2021-03-16T20:59:20Z | |
dc.date.issued | 2021-02-01T00:00:00Z | |
dc.description.abstract | Background: There is growing evidence indicating that children are less affected from COVID-19. Some authors speculate that childhood vaccinations may provide some cross-protection against COVID-19. In this study, our aim was to compare the circulating antibody titers for multiple childhood vaccine antigens, as an indicator of the state of immune memory between patients with COVID-19 and healthy controls, with a specific aim to identify the association between disease severity and antibody titrations which may indicate a protective function related to vaccine or disease induced memory. Methods: This study is a case-control study including 53 patients with COVID-19 and 40 healthy volunteers. COVID-19 severity was divided into three groups: asymptomatic, mild and severe. We measured the same set of antibody titers for vaccine antigens, and a set of biochemical and infection markers, in both the case and control groups. Results: Rubella (p = 0.003), pneumococcus (p = 0.002), and Bordetella pertussis (p < 0.0001) titers were found to be significantly lower in the case group than the control group. There was a significant decline in pneumococcus titers with severity of disease (p = 0.021) and a significant association with disease severity for Bordetella pertussis titers (p = 0.014) among COVID patients. Levels of AST, procalcitonin, ferritin and D-dimer significantly increased with the disease severity. Discussion: Our study supports the hypothesis that pre-existing immune memory, as monitored using circulating antibodies, acquired from childhood vaccinations, or past infections confer some protection against COVID-19. Randomized controlled studies are needed to support a definitive conclusion | |
dc.identifier.citation | SÜMBÜL B., Sumbul H. E. , OKYAY R. A. , Gulumsek E., ŞAHİN A. R. , Boral B., Kocyigit B. F. , Alfishawy M., Gold J., Tasdogan A. M. , -Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study-, PEERJ, cilt.9, 2021 | |
dc.identifier.doi | 10.7717/peerj.10910 | |
dc.identifier.pubmed | 33614298 | |
dc.identifier.scopus | 85100928113 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12645/28591 | |
dc.identifier.uri | https://peerj.com/articles/10910/ | |
dc.identifier.wos | WOS:000616406800016 | |
dc.subject | COVID-19 | |
dc.subject | Cross-protection | |
dc.subject | Pandemic | |
dc.subject | Antibody titers | |
dc.title | Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.avesis.id | aa88c2ad-5380-4c3f-9e1a-6d8378bdc646 | |
local.indexed.at | PubMed | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
local.publication.goal | 03 - Sağlık ve Kaliteli Yaşam | |
local.publication.isinternational | 1 | |
relation.isAuthorOfPublication | 51568f47-69f1-46a2-b201-e6d6161080a8 | |
relation.isAuthorOfPublication.latestForDiscovery | 51568f47-69f1-46a2-b201-e6d6161080a8 | |
relation.isGoalOfPublication | 9c198c48-b603-4e2f-8366-04edcfc1224c | |
relation.isGoalOfPublication.latestForDiscovery | 9c198c48-b603-4e2f-8366-04edcfc1224c |
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