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Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study

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dc.contributor.authorSÜMBÜL, BİLGE
dc.contributor.authorSumbul, Hilmi Erdem
dc.contributor.authorOKYAY, RAMAZAN AZİM
dc.contributor.authorGulumsek, Erdinc
dc.contributor.authorŞAHİN, AHMET RIZA
dc.contributor.authorBoral, Baris
dc.contributor.authorKocyigit, Burhan Fatih
dc.contributor.authorAlfishawy, Mostafa
dc.contributor.authorGold, Jeffrey
dc.contributor.authorTasdogan, Ali Muhittin
dc.contributor.institutionauthorSÜMBÜL, BİLGE
dc.date.accessioned2021-03-16T20:59:20Z
dc.date.available2021-03-16T20:59:20Z
dc.date.issued2021-02-01T00:00:00Z
dc.description.abstractBackground: There is growing evidence indicating that children are less affected from COVID-19. Some authors speculate that childhood vaccinations may provide some cross-protection against COVID-19. In this study, our aim was to compare the circulating antibody titers for multiple childhood vaccine antigens, as an indicator of the state of immune memory between patients with COVID-19 and healthy controls, with a specific aim to identify the association between disease severity and antibody titrations which may indicate a protective function related to vaccine or disease induced memory. Methods: This study is a case-control study including 53 patients with COVID-19 and 40 healthy volunteers. COVID-19 severity was divided into three groups: asymptomatic, mild and severe. We measured the same set of antibody titers for vaccine antigens, and a set of biochemical and infection markers, in both the case and control groups. Results: Rubella (p = 0.003), pneumococcus (p = 0.002), and Bordetella pertussis (p < 0.0001) titers were found to be significantly lower in the case group than the control group. There was a significant decline in pneumococcus titers with severity of disease (p = 0.021) and a significant association with disease severity for Bordetella pertussis titers (p = 0.014) among COVID patients. Levels of AST, procalcitonin, ferritin and D-dimer significantly increased with the disease severity. Discussion: Our study supports the hypothesis that pre-existing immune memory, as monitored using circulating antibodies, acquired from childhood vaccinations, or past infections confer some protection against COVID-19. Randomized controlled studies are needed to support a definitive conclusion
dc.identifier.citationSÜMBÜL B., Sumbul H. E. , OKYAY R. A. , Gulumsek E., ŞAHİN A. R. , Boral B., Kocyigit B. F. , Alfishawy M., Gold J., Tasdogan A. M. , -Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study-, PEERJ, cilt.9, 2021
dc.identifier.doi10.7717/peerj.10910
dc.identifier.pubmed33614298
dc.identifier.scopus85100928113
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28591
dc.identifier.urihttps://peerj.com/articles/10910/
dc.identifier.wosWOS:000616406800016
dc.subjectCOVID-19
dc.subjectCross-protection
dc.subjectPandemic
dc.subjectAntibody titers
dc.titleIs there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study
dc.typeArticle
dspace.entity.typePublication
local.avesis.idaa88c2ad-5380-4c3f-9e1a-6d8378bdc646
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication51568f47-69f1-46a2-b201-e6d6161080a8
relation.isAuthorOfPublication.latestForDiscovery51568f47-69f1-46a2-b201-e6d6161080a8
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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