A Basic Algorithmic Surgical Approach for Nicolau Syndrome

No Thumbnail Available
Yeniocak, Ali
Güneren, Ethem
Özkan, Mustafa
Temel, Metin
Kelahmetoğlu, Osman
Journal Title
Journal ISSN
Volume Title
Research Projects
Organizational Units
Journal Issue


Search on Google Scholar

Background: Nicolau syndrome (NS) is a rare complication that develops after the administration of intramuscular diclofenac sodium. The etiology and surgical treatments of 11 patients with NS were evaluated and studies in the literature were examined. The aim of this study was to compose a basic algorithm for surgical approaches to treat NS. Materials and methods: Eleven patients were evaluated for NS between December 2013 and January 2018. Two patients did not accept treatment, and nine patients underwent surgical debridement of necrotic tissues. The tissue defects of five patients were closed with a fasciocutaneous flap and, in four patients, the defects were repaired primarily. Results: No complications, such as wound infection, wound dehiscence, seroma, or flap necrosis, were encountered. Of the seven patients who received concurrent antibiotic therapy, no patient had any problems at their follow-up (2-30 months). The results were satisfactory from an aesthetic and functional point of view. Conclusion: NS was more frequent in women with a high body mass index and high fat in gluteal regions. We considered that any kind of medication could lead to NS. Different methods are discussed for treatment.
Nicolau Syndrome, Diclofenac sodium
Yeniocak A., Kelahmetoğlu O., Özkan M., Temel M., Güneren E., -A Basic Algorithmic Surgical Approach for Nicolau Syndrome-, Journal of Cutaneous and Aesthetic Surgery, cilt.13, ss.154-159, 2020
Page Views


File Downloads


Sustainable Development Goals