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Effects of ceftriaxone on ischemia/reperfusion injury in rat brain

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dc.contributor.authorAltas, M.
dc.contributor.authorMeydan, SEDAT
dc.contributor.authorAras, M.
dc.contributor.authorYilmaz, N.
dc.contributor.authorUlutas, K. T.
dc.contributor.authorOkuyan, H. M.
dc.contributor.authorNacar, A.
dc.contributor.institutionauthorMEYDAN, SEDAT
dc.date.accessioned2020-10-29T18:33:31Z
dc.date.available2020-10-29T18:33:31Z
dc.date.issued2013-03-01T00:00:00Z
dc.description.abstractThe aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n = 10), I/R group (n = 10) and I/R-ceftriaxone group (n = 10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p < 0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p < 0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue. (C) 2012 Elsevier Ltd. All rights reserved.
dc.identifier.citationAltas M., Meydan S., Aras M., Yilmaz N., Ulutas K. T. , Okuyan H. M. , Nacar A., -Effects of ceftriaxone on ischemia/reperfusion injury in rat brain-, JOURNAL OF CLINICAL NEUROSCIENCE, cilt.20, ss.457-461, 2013
dc.identifier.doi10.1016/j.jocn.2012.05.030
dc.identifier.scopus84875226790
dc.identifier.urihttp://hdl.handle.net/20.500.12645/25785
dc.identifier.wosWOS:000316839900025
dc.titleEffects of ceftriaxone on ischemia/reperfusion injury in rat brain
dc.typeArticle
dspace.entity.typePublication
local.avesis.id4948109e-7af7-4d7d-928a-6a3b53f3680f
local.publication.isinternational1
relation.isAuthorOfPublication911e6cc8-a491-428f-b583-ec1b86181c34
relation.isAuthorOfPublication.latestForDiscovery911e6cc8-a491-428f-b583-ec1b86181c34
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