Publication: Cerium nitrate treatment prevents progressive tissue necrosis in the zone of stasis following burn
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Date
2012-03-01T00:00:00Z
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Eski, Muhitdin
Ozer, Firat
Firat, Cemal
Alhan, Dogan
Arslan, Nuri
Senturk, Tolga
Isik, Selcuk
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Abstract
Cerium nitrate (CN) was used as a topical antiseptic agent for the treatment of burn wounds and found to reduce the number of anticipated death in burn. This decreased burn related mortality cannot be explained by the control of wound infection alone. In the studies performed to elucidate the unexplained effects of CN treatment, it was shown that CN treatment reduced the alarm cytokine levels, decreased leukocyte activation, reduced macromolecular leakage and finally burn edema formation. We hypothesized that CN treatment prevents the conversion of the zone of stasis to progressive tissue necrosis by decreasing leukocyte activation and reducing macromolecular leakage and burn edema.
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Eski M., Ozer F., Firat C., Alhan D., Arslan N., Senturk T., Isik S., -Cerium nitrate treatment prevents progressive tissue necrosis in the zone of stasis following burn-, BURNS, cilt.38, ss.283-289, 2012