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Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)

dc.contributor.authorYilmaz Ciftdogan, Dilek
dc.contributor.authorEkemen Keles, Yildiz
dc.contributor.authorKarbuz, Adem
dc.contributor.authorÇETİN, BENHUR ŞİRVAN
dc.contributor.authorElmas Bozdemir, Sefika
dc.contributor.authorKEPENEKLİ KADAYİFCİ, EDA
dc.contributor.authorMetin Akcan, Ozge
dc.contributor.authorOzer, Arife
dc.contributor.authorErat, Tugba
dc.contributor.authorSutcu, Murat
dc.contributor.authorBuyukcam, Ayse
dc.contributor.authorBELET, NURŞEN
dc.contributor.authorErdeniz, Emine Hafize
dc.contributor.authorDalgic Karabulut, Nazan
dc.contributor.authorHancerli Torun, Selda
dc.contributor.authorÖNCEL, SELİM
dc.contributor.authorORBAK, Zerrin
dc.contributor.authorTÜREL, Özden
dc.contributor.authorGAYRETLİ AYDIN, ZEYNEP GÖKÇE
dc.contributor.authorKILIÇ, ÖMER
dc.contributor.authorYahsi, Aysun
dc.contributor.authorKara Aksay, Ahu
dc.contributor.authorErgenc, Zeynep
dc.contributor.authorPetmezci, Mey Talip
dc.contributor.authorOFLAZ, MEHMET BURHAN
dc.contributor.authorSarikaya, Remzi
dc.contributor.authorOtar Yener, Gulcin
dc.contributor.authorOzen, Seval
dc.contributor.authorGul, Doruk
dc.contributor.authorARSLAN, GAZİ
dc.contributor.authorKara, Soner Sertan
dc.contributor.authorDemirkol, Demet
dc.contributor.authorYAZICI ÖZKAYA, PINAR
dc.contributor.authorYOZGAT, YILMAZ
dc.contributor.authorVaran, Celal
dc.contributor.authorKara, Manolya
dc.contributor.authorARGA, GÜL
dc.contributor.authorYAKUT, NURHAYAT
dc.contributor.authorKilic, Ahmet Osman
dc.contributor.authorÇAKICI, ÖZLEM
dc.contributor.authorKucuk, Mehmet
dc.contributor.authorKaba, Ozge
dc.contributor.authorKARAOĞLU ASRAK, HATİCE
dc.contributor.authorBURSAL DURAMAZ, BURCU
dc.contributor.authorDalkiran, Tahir
dc.contributor.authorBerna Anil, Ayse
dc.contributor.authorTURĞUT, MEHMET
dc.contributor.authorKARAPINAR, BÜLENT
dc.contributor.authorSomer, Ayper
dc.contributor.authorELMALI, FERHAN
dc.contributor.authorDİNLEYİCİ, ENER ÇAĞRI
dc.contributor.authorÇİFTCİ, ERGİN
dc.contributor.authorKARA, ATEŞ
dc.contributor.institutionauthorTÜREL, ÖZDEN
dc.contributor.institutionauthorYOZGAT, YILMAZ
dc.contributor.institutionauthorBURSAL DURAMAZ, BURCU
dc.date.accessioned2022-03-08T20:59:06Z
dc.date.available2022-03-08T20:59:06Z
dc.date.issued2022-02-01T00:00:00Z
dc.description.abstractAim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients- medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.
dc.identifier.doi10.1111/jpc.15913
dc.identifier.pubmed35199895
dc.identifier.scopus85125111465
dc.identifier.urihttp://hdl.handle.net/20.500.12645/30432
dc.identifier.wosWOS:000760265600001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectKawasaki disease
dc.subjectMIS-C
dc.subjectchild
dc.subjectshock
dc.titleMultisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)
dc.typeArticle
dspace.entity.typePublication
local.avesis.idfa56ec26-8d84-44cf-9c8c-eaec75138586
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
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