Publication:
Lecithin-acrylamido-2-methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrier

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dc.contributor.authorMutlu, Esra Cansever
dc.contributor.authorBostan, Muge Sennaroglu
dc.contributor.authorBahadori, FATEMEH
dc.contributor.authorKocyigit, ABDÜRRAHİM
dc.contributor.authorOner, Ebru Toksoy
dc.contributor.authorEROĞLU, MEHMET SAYIP
dc.contributor.institutionauthorBAHADORİ, FATEMEH
dc.contributor.institutionauthorKOÇYİĞİT, ABDÜRRAHİM
dc.date.accessioned2019-10-05T15:21:07Z
dc.date.available2019-10-05T15:21:07Z
dc.date.issued2016-11-10
dc.description.abstractIn this study, a novel paclitaxel (PTX) loaded and a crosslinked solid phospholipid nanoparticles (SLN-PTX) with negative surface charge was prepared by UV polymerization for drug delivery. Capping of positive charge of zwitterionic lecithin with negative charge of sodium 2-acrylamido-2-methyl-1-propanesulfonate (AMPS-Na) through cation exchange interaction produced a lecithin-AMPS (L-AMPS) complex. The amphiphilic and negative charged lipid complex was emulsified in the presence of emulsifier, paclitaxel, initiator, and methacrylated poly epsilon-caprolacton-diol (PCL-MAC) as a spacer. The colloidal system was subjected to UV-irradiation to obtain crosslinked nanoparticles. Completion of the UV-polymerization was monitored with differential scanning calorimetry (DSC), which indicated the disappearance of exothermic peaks of vinyl groups. The nanoparticle system, having an average size of 200 nm, exhibited high drug encapsulation (96%) with negatively charged surface (zeta potential had an average of -70 mV). PTX release profiles of the crosslinked and uncrosslinked SLN-PTXs were studied and their pharmacological properties were compared. The crosslinked nanoparticles exhibited more controlled release behavior with longer release time compared to the uncrosslinked ones. In vitro cytotoxicity test was conducted on MCF-7 human breast adenocarcinoma cell line, which indicated that the crosslinked SLN-PTXs have a potential therapeutic effect for breast cancer treatments. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44105.
dc.identifier10.1002/pola.23007
dc.identifier.citationMutlu E. C. , Bostan M. S. , Bahadori F., Kocyigit A., Oner E. T. , EROĞLU M. S. , -Lecithin-acrylamido-2-methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrier-, JOURNAL OF APPLIED POLYMER SCIENCE, cilt.133, 2016
dc.identifier.doi10.1002/app.44105
dc.identifier.scopus84982803953
dc.identifier.urihttps://hdl.handle.net/20.500.12645/6073
dc.identifier.wosWOS:000380723800007
dc.language.isoen
dc.titleLecithin-acrylamido-2-methylpropane sulfonate based crosslinked phospholipid nanoparticles as drug carrier
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
local.avesis.id96b4f8ef-5c68-4e14-907e-8e7c6b287509
local.avesis.response5943
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
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relation.isAuthorOfPublication.latestForDiscovery14c64c63-5d3c-42d0-9f93-cf4b7af6da81
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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