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Neovascularization of engineered tissues for clinical translation: Where we are, where we should be?

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dc.contributor.authorNazeer, Muhammad Anwaar
dc.contributor.authorKaraoglu, Ismail Can
dc.contributor.authorOzer, Onur
dc.contributor.authorAlbayrak, Cem
dc.contributor.authorKizilel, Seda
dc.contributor.institutionauthorALBAYRAK, CEM
dc.date.accessioned2021-04-20T20:59:06Z
dc.date.available2021-04-20T20:59:06Z
dc.date.issued2021-06-01T00:00:00Z
dc.description.abstractOne of the key challenges in engineering three-dimensional tissue constructs is the development of a mature microvascular network capable of supplying sufficient oxygen and nutrients to the tissue. Recent angiogenic therapeutic strategies have focused on vascularization of the constructed tissue, and its integration in vitro; these strategies typically combine regenerative cells, growth factors (GFs) with custom-designed biomaterials. However, the field needs to progress in the clinical translation of tissue engineering strategies. The article first presents a detailed description of the steps in neovascularization and the roles of extracellular matrix elements such as GFs in angiogenesis. It then delves into decellularization, cell, and GF-based strategies employed thus far for therapeutic angiogenesis, with a particularly detailed examination of different methods by which GFs are delivered in biomaterial scaffolds. Finally, interdisciplinary approaches involving advancement in biomaterials science and current state of technological development in fabrication techniques are critically evaluated, and a list of remaining challenges is presented that need to be solved for successful translation to the clinics.
dc.description.sponsorshipTürkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak )
dc.identifier.citationNazeer M. A. , Karaoglu I. C. , Ozer O., Albayrak C., Kizilel S., -Neovascularization of engineered tissues for clinical translation: Where we are, where we should be?-, APL BIOENGINEERING, cilt.5, sa.2, 2021
dc.identifier.doi10.1063/5.0044027
dc.identifier.scopus85103785660
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28793
dc.identifier.wosWOS:000636808900001
dc.titleNeovascularization of engineered tissues for clinical translation: Where we are, where we should be?
dc.typeArticle
dspace.entity.typePublication
local.avesis.ideb25974f-b0fb-45a3-a508-2b6883c468b4
local.publication.isinternational1
relation.isAuthorOfPublicationced2804c-b9e5-4f25-9926-74404ade4f49
relation.isAuthorOfPublication.latestForDiscoveryced2804c-b9e5-4f25-9926-74404ade4f49
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