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Development and validation of a GC-FID method to quantify thymoquinone in black cumin seed oils

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dc.contributor.authorDemirbolat, Ilker
dc.contributor.authorKARTAL, MURAT
dc.contributor.authorKarik, Unal
dc.contributor.institutionauthorKARTAL, MURAT
dc.date.accessioned2020-01-13T20:59:40Z
dc.date.available2020-01-13T20:59:40Z
dc.date.issued2019-01-01T00:00:00Z
dc.description.abstractBlack cumin (Nigella sativa L.) is a very popular medicinal plant around the world. Pharmacological effects have been widely studied over the years. It has an economic importance and being cultivated in many parts of Turkey and neighbour countries. Thymoquinone (TQ) is a volatile compound found in black cumin seeds and a major compound of its essential and fixed oils which has been reported as anticancer, antidiabetic, spasmolytic, immunomodulator, bronchodilator, antimicrobial, analgesic, anti-inflammatory, antioxidant etc. The quality of black cumin seed oil depends on extraction technics (expression, super critic CO2 extraction etc.), quality of seeds, storage time and thymoquinone content. In this study we developed and validated a rapid quantification GC-FID method to determine the thymoquinone levels in seed oils which uses diethyl phthalate (DEP) as an internal standard.
dc.identifier.citationDemirbolat I., KARTAL M., Karik U., -Development and validation of a GC-FID method to quantify thymoquinone in black cumin seed oils-, JOURNAL OF RESEARCH IN PHARMACY, cilt.23, ss.506-513, 2019
dc.identifier.doi10.12991/jrp.2019.157
dc.identifier.scopus85067053570
dc.identifier.trdizintrdizin
dc.identifier.urihttps://openaccess.bezmialem.edu.tr/handle/20.500.12645/12291
dc.identifier.wosWOS:000468157000016
dc.titleDevelopment and validation of a GC-FID method to quantify thymoquinone in black cumin seed oils
dc.typeArticle
dspace.entity.typePublication
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local.publication.goal02 - Açlığa Son
local.publication.isinternational1
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relation.isGoalOfPublication.latestForDiscovery5246edf8-60d4-4a7b-9a27-c73e4a636141
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