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Evaluation of amblyopic eyes with optical coherence tomography angiography and electrophysiological tests

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dc.contributor.authorHamurcu, Mualla
dc.contributor.authorEKİNCİ, CANSU
dc.contributor.authorKoca, Semra
dc.contributor.authorTUĞCU, Betül
dc.contributor.institutionauthorEKİNCİ, CANSU
dc.contributor.institutionauthorTUĞCU, BETÜL
dc.date.accessioned2021-01-19T20:59:51Z
dc.date.available2021-01-19T20:59:51Z
dc.date.issued2021-01-01T00:00:00Z
dc.description.abstractPurpose: To investigate the structural and functional changes of the retina and optic nerve in amblyopia. Methods: Eighteen patients with unilateral anisometropic amblyopia and 27 age-matched healthy controls were involved in this study. All patients underwent optical coherence tomography angiography (OCTA), pattern visual evoked potential (pVEP), and flash electroretinogram (fERG). Results: There was no statistically significant difference in terms of the fovea] avascular zone (FAZ), perifoveal superficial density, whole superficial density, parafoveal deep density, perifoveal deep density among the eyes (P > 0 0.05). Significant differences were found only in superficial capillary plexus (SCP) vessel density in whole (P = 0.029) and parafoveal (P = 0.008) image. In electrophysiological tests, while VEP latencies of the amblyopic eyes increased compared to nonamblyopic eyes and controls (P = 0.027), VEP amplitudes decreased in amblyopic and nonamblyopic eyes compared to controls (P = 0.01), amplitudes of the rod (P = 0.027) and cones (P < 0.001) also decreased in amblyopic eyes compared to nonamblyopic and healthy eyes. When we assessed the correlation between the parameters of OCTA and electrophysiological test, only a significant correlation was found between parafoveal SCP vessel density and VEP amplitudes (r = 0.341). Conclusion: We found a significant decrease only in SCP vessel density of the OCTA parameters in amblyopic eyes compared to healthy eyes. We detected a significant relationship between parafoveal SCP vessel density and VEP parameters, which might be associated with the underlying pathophysiology of the amblyopia.
dc.identifier.citationHamurcu M., EKİNCİ C., Koca S., TUĞCU B., -Evaluation of amblyopic eyes with optical coherence tomography angiography and electrophysiological tests-, INDIAN JOURNAL OF OPHTHALMOLOGY, cilt.69, ss.105-110, 2021
dc.identifier.doi10.4103/ijo.ijo_2319_19
dc.identifier.pubmed33323589
dc.identifier.scopus85098147181
dc.identifier.urihttp://hdl.handle.net/20.500.12645/28009
dc.identifier.wosWOS:000601311400030
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmblyopia
dc.subjectelectroretinography
dc.subjectoptical coherence tomographic angiography
dc.subjectretina
dc.subjectvisual evoked potential
dc.titleEvaluation of amblyopic eyes with optical coherence tomography angiography and electrophysiological tests
dc.typeArticle
dspace.entity.typePublication
local.avesis.id7ba20efb-5eed-443a-811d-a7a42f03915d
local.publication.isinternational1
relation.isAuthorOfPublication52c836c8-0c87-4e69-8fd3-0f49e9a5dea7
relation.isAuthorOfPublication14827d60-5a60-4332-82d8-cfd0b8a19287
relation.isAuthorOfPublication.latestForDiscovery52c836c8-0c87-4e69-8fd3-0f49e9a5dea7
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Evaluation of amblyopic eyes with optical coherence tomography angiography and electrophysiological tests
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