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Vitamin D Deficiency and Insufficiency in Obese Children and Adolescents and Its Relationship with Insulin Resistance

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dc.contributor.authorTorun, EMEL
dc.contributor.authorGONULLU, Erdem
dc.contributor.authorOzgen, Ilker Tolga
dc.contributor.authorCINDEMIR, Ergul
dc.contributor.authorOKTEM, Faruk
dc.contributor.institutionauthorTORUN, EMEL
dc.contributor.institutionauthorÖZGEN, İLKER TOLGA
dc.date.accessioned2019-10-05T21:35:48Z
dc.date.available2019-10-05T21:35:48Z
dc.date.issued2013-01-01
dc.description.abstractObjectives. We aimed to determine the relationship between insulin resistance and serum 25-hydroxyvitamin D (25-OHD) levels in obese children and their nonobese peers. Materials and Methods. Included in the study group were 188 obese children (aged 9-15 years), and 68 age- and gender-matched healthy children of normal weight as control group. Anthropomorphic data were collected on patients and fasting serum glucose, insulin, serum lipids, alanine aminotransaminase (ALT) and 25-OHD were measured. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated in both groups. Results. The levels of 25-OHD in the obese group were significantly lower than those of the nonobese (P = 0.002). HOMA-IR, triglycerides, low-density lipoprotein, and ALT levels in the obese group were significantly higher than values of control group (P < 0.001 and P = 0.002, resp.). In the obese group, vitamin D deficiency, insufficiency, and sufficiency (25-OHD < 10 ng/dl, < 20, >10 ng/dl; > 20 ng/dl, resp.) were not correlated with HOMA-IR (r : -0.008, P = 0.935). HOMA-IR was negatively correlated with BMI, BMI SDS, and BMI%, and triglycerides, low-density lipoprotein, and ALT levels (P < 0.001). Conclusion. The insulin resistance of the obese subjects who were vitamin D deficient and insufficient did not statistically differ from those with vitamin D sufficiency. Low 25-hydroxyvitamin D levels were not related with higher insulin resistance in obese children and adolescents. In obese subjects, insulin resistance was affected more from BMI, BMI SDS, and BMI% than from 25-hydroxyvitamin D levels.en
dc.identifier10.1007/s00405-010-1339-3
dc.identifier.citationTorun E., GONULLU E., Ozgen I. T. , CINDEMIR E., OKTEM F., -Vitamin D Deficiency and Insufficiency in Obese Children and Adolescents and Its Relationship with Insulin Resistance-, INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013
dc.identifier.pubmed23606841
dc.identifier.urihttps://hdl.handle.net/20.500.12645/7711
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleVitamin D Deficiency and Insufficiency in Obese Children and Adolescents and Its Relationship with Insulin Resistance
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
local.avesis.idbf6394a6-286b-4e02-bc57-aa4f6323d49b
local.avesis.response7587
relation.isAuthorOfPublication12c436eb-39a7-43ce-b99f-c585a4499848
relation.isAuthorOfPublicationc6ad9225-905e-4761-8da0-36efba996f82
relation.isAuthorOfPublication.latestForDiscovery12c436eb-39a7-43ce-b99f-c585a4499848
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