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Plasma levels and distribution of gene polymorphisms of factor VII in Turkish population.

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dc.contributor.authorTurfan, Murat
dc.contributor.authorPoyraz, Fatih
dc.contributor.authorKaymak, Aysegül Öztürk
dc.contributor.authorErgun, Mehmet Ali
dc.contributor.authorTavil, Yusuf
dc.contributor.authorGursel, Turkiz
dc.contributor.authorAbaci, Adnan
dc.date.accessioned2023-05-16T16:53:05Z
dc.date.available2023-05-16T16:53:05Z
dc.date.issued2014-02-28T22:00:00Z
dc.description.abstractThree factor VII (FVII) promoter haplotypes are associated with stratified plasma FVII levels. To our knowledge, this is the first study examining the distribution of FVII gene polymorphism and levels in Turkish population. The study population was classified into 3 groups according to the absence of coronary arterial disease and presence or absence of a history of myocardial infarction. It was found that the levels of FVII coagulant activity (FVIIc) were higher in the event group than that of the other groups. Participants with high FVIIc levels were found to have 2-fold increased risk for myocardial infarction. The alleles at the FVII loci in all cases are similar. In conclusion, our results indicate that FVIIc levels have an important predictive role in cardiovascular events. The distribution of FVII gene polymorphisms in the Turkish population shows significant differences when compared with European populations.
dc.identifier.pubmed22964781
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38236
dc.language.isoen
dc.subjectFVIIa
dc.subjectTurkish
dc.subjectatherosclerosis
dc.subjectcardiology
dc.subjectgene polymorphisms
dc.subjectthrombosis
dc.titlePlasma levels and distribution of gene polymorphisms of factor VII in Turkish population.
dspace.entity.typePublication
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