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High D-dimer levels are associated with prostate cancer

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dc.contributor.authorKALKAN, Senad
dc.contributor.authorCaliskan, Selahattin
dc.contributor.institutionauthorKALKAN, SENAD
dc.date.accessioned2020-09-01T21:00:41Z
dc.date.available2020-09-01T21:00:41Z
dc.date.issued2020-05-01T00:00:00Z
dc.description.abstractProstate cancer is one of the most common types of cancer among men in the world1 and a significant health problem in developed and developing countries2 . The association between cancer and hemostasis has been shown in several studies3 . The main risk factors for coagulation activation and thrombosis are aging and malignancy4 . The increased risk of thrombosis in cancer patients may be associated with high levels of coagulation markers (fibrinogen), and thrombogenesis markers (D-dimer) are likely evidence of this process5 . Fibrinogen is an acute-phase protein that is mainly synthesized by hepatocytes and converted into insoluble fibrin by activated thrombin. It is also an important indicator of the coagulation system6 . The plasma fibrinogen level increases in some circumstances, such as malignancy and systemic inflammation. D-dimer is a degradation product of fibrin which is produced by plasmin-induced fibrinolytic activity7 . It is a biomarker that indicates the activation of hemostasis and fibrinolysis. Elevated plasma levels may be associated with some scenarios such as cancer, pregnancy, infectious diseases, trauma, surgery, and venous thromboembolism. When fibrinogen levels are increased, they are deemed to be an unfavorable prognostic factor in some malignancies, such as those of the digestive system, gynecologic malignancies, urologic neoplasms, and soft tissue sarcomas6 . A high level of D-dimer is a prognostic factor associated with increased mortality risk in patients with brain tumors, lymphomas, breast, lung, stomach, colorectal, pancreatic, and prostate cancers7 . We investigated the levels of D-dimer and fibrinogen in patients with prostate cancer and benign prostate hyperplasia.
dc.identifier.citationKALKAN S., Caliskan S., -High D-dimer levels are associated with prostate cancer-, REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, cilt.66, ss.649-653, 2020
dc.identifier.doi10.1590/1806-9282.66.5.649
dc.identifier.pubmed32638959
dc.identifier.scopus85087663799
dc.identifier.urihttp://hdl.handle.net/20.500.12645/18555
dc.identifier.urihttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000500649&lng=en&nrm=iso&tlng=en
dc.identifier.wosWOS:000546930300021
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProstate canceren
dc.subjectCancer
dc.titleHigh D-dimer levels are associated with prostate cancer
dc.typeArticle
dspace.entity.typePublication
local.avesis.ida48c7551-96a5-4f30-a6a6-f177c91b5275
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication5001de04-30d2-46b4-9d55-f4db0093202a
relation.isAuthorOfPublication.latestForDiscovery5001de04-30d2-46b4-9d55-f4db0093202a
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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