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Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3

dc.contributor.authorÇETİN Ç.
dc.contributor.authorOkten S. B.
dc.contributor.authorTOK O. E.
dc.contributor.authorOzcan P.
dc.contributor.authorGÖKMEN KARASU A. F.
dc.contributor.authorTanoglu F. B.
dc.contributor.authorTaha H. S.
dc.contributor.authorATEŞ S.
dc.contributor.institutionauthorÇETİN, ÇAĞLAR
dc.contributor.institutionauthorÖZCAN, PINAR
dc.contributor.institutionauthorGÖKMEN KARASU, AYŞE FİLİZ
dc.contributor.institutionauthorTANOĞLU, FATMA BAŞAK
dc.contributor.institutionauthorATEŞ, SEDA
dc.date.accessioned2024-01-31T21:50:37Z
dc.date.available2024-01-31T21:50:37Z
dc.date.issued2024-01-01
dc.description.abstractObjective: To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy). Materials and Methods: Forty-two Sprague–Dawley rats were randomly allocated into seven distinct groups as; Group 1(control): NaCl intraperitoneal (IP) injection was administered on days D1, D7, and D14. Group 2(Cy):Cy IP injection on D1 + NaCl IP injection on D7 and D14 were administered. Group 3(PRP): PRP IP injection on D1,D7 and D14 were administered. Group 4(Cy + PRP):Cy IP injection on D1 and PRP IP injection on D1, D7 and D14 were administered. Group 5(G-CSF): G-CSF IP injection on D1, D7 and D14 were administered. Group 6(Cy + G-CSF):Cy IP injection on D1+ G-CSF IP injection on D1, D7 and D14 were administered. Group 7(Cy + PRP + G-CSF):Cy IP injection on D1+ PRP IP injection on D1,D7 and D14+ G-CSF IP injection on D1,D7 and D14 were administered. Follicular number, histological scores of AMH and INSL3 stained follicles at different stages of follicular development, and serum Anti-Müllerian hormone(AMH) were evaluated. Results: The primary, secondary, and antral follicle intensity scores for AMH-positive staining were most prominent in Groups 3 and 5. There was no significant difference between groups 4, 6 and 7 compared to group 1 in terms of follicule counts and AMH staining. The intensity scores of AMH-positive staining follicles were notably reduced in group 2 compared to groups 4, 6, and 7, with a significant difference (p <.01). Among the groups, group 2 exhibited the least intense antral follicle staining for INSL3, displaying a significant difference(p <.01) compared to the remaining groups. Conclusions: Autologous PRP and G-CSF might protect ovarian function in the face of ovarian damage caused by Cy-induced effects.
dc.identifier.citationÇETİN Ç., Okten S. B., TOK O. E., Ozcan P., GÖKMEN KARASU A. F., Tanoglu F. B., Taha H. S., ATEŞ S., "Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3", Gynecological Endocrinology, cilt.40, sa.1, 2024
dc.identifier.doi10.1080/09513590.2023.2301551
dc.identifier.issn0951-3590
dc.identifier.issue1
dc.identifier.pubmed38195404
dc.identifier.scopus85181897266
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85181897266&origin=inward
dc.identifier.urihttps://hdl.handle.net/20.500.12645/39009
dc.identifier.volume40
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectSurgery Medicine Sciences
dc.subjectObstetrics and Gynecology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectOBSTETRICS & GYNECOLOGY
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectDoğum ve Jinekoloji
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectLife Sciences
dc.subjectFollicle
dc.subjectG-csf
dc.subjectINSL3 ovary
dc.subjectovarian failure
dc.subjectplatelet-rich plasma
dc.titleTreatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3
dc.typearticle
dspace.entity.typePublication
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