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Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.

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Date
2022-10-13T00:00:00Z
Authors
Wainberg, Zev A
Enzinger, Peter C
Kang, Yoon-Koo
Qin, Shukui
Yamaguchi, Kensei
Kim, In-Ho
Saeed, Anwaar
Oh, Sang Cheul
Li, Jin
Turk, HACI MEHMET
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Abstract
Magnetic monopoles are known to emerge as leading non-perturbative fluctuations in the lattice version of non-Abelian gauge theories in some gauges. In terms of the Dirac quantization condition, these monopoles have magnetic charge |Q_M|=2. Also, magnetic monopoles with |Q_M|=1 can be introduced on the lattice via the -t Hooft loop operator. We consider the |Q_M|=1,2 monopoles in the continuum limit of the lattice gauge theories. To substitute for the Dirac strings which cost no action on the lattice, we allow for singular gauge potentials which are absent in the standard continuum version. Once the Dirac strings are allowed, it turns possible to find a solution with zero action for a monopole--antimonopole pair. This implies equivalence of the standard and modified continuum versions in perturbation theory. To imitate the nonperturbative vacuum, we introduce then a nonsingular background. The modified continuum version of the gluodynamics allows in this case for monopoles with finite non-vanishing action. Using similar techniques, we construct the -t Hooft loop operator in the continuum and predict its behavior at small and large distances both at zero and high temperatures.
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Wainberg Z. A. , Enzinger P. C. , Kang Y., Qin S., Yamaguchi K., Kim I., Saeed A., Oh S. C. , Li J., Turk H. M. , et al., -Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.-, The Lancet. Oncology, 2022
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