Publication:
Melatonin protects against ischemic heart failure in rats

Simple item page
dc.contributor.authorSehirli, Ahmet Ozer
dc.contributor.authorKoyun, Derya
dc.contributor.authorTETİK, ŞERMİN
dc.contributor.authorÖZSAVCI, DERYA
dc.contributor.authorYIGINER, Omer
dc.contributor.authorÇETİNEL, ŞULE
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorKaya, Zehra
dc.contributor.authorAKKİPRİK, MUSTAFA
dc.contributor.authorKilic, Ertugrul
dc.contributor.authorSener, Goksel
dc.contributor.institutionauthorTOK, OLGU ENİS
dc.date.accessioned2020-10-29T22:44:22Z
dc.date.available2020-10-29T22:44:22Z
dc.date.issued2013-09-01T00:00:00Z
dc.description.abstractIschemic injury, which occurs as a result of sympathetic hyperactivity, plays an important role in heart failure. Melatonin is thought to have antiatherogenic, antioxidant, and vasodilatory effects. In this study, we investigated whether melatonin protects against ischemic heart failure (HF). In Wistar albino rats, HF was induced by left anterior descending (LAD) coronary artery ligation and rats were treated with either vehicle or melatonin (10 mg/kg) for 4 weeks. At the end of this period, echocardiographic measurements were recorded and the rats were decapitated to obtain plasma and cardiac tissue samples. Lactate dehydrogenase, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lysosomal enzymes (beta-D-glucuronidase, beta-galactosidase, beta-D-N-acetyl-glucosaminidase, acid phosphatase, and cathepsin-D) were studied in plasma samples, while malondialdehyde and glutathione levels and Na+, K+-ATPase, caspase-3 and myeloperoxidase activities were determined in the cardiac samples. Sarco/endoplasmic reticulum calcium ATPase (SERCA) and caveolin-3 levels in cardiac tissues were evaluated using Western blot analyses. Furthermore, caveolin-3 levels were also determined by histological analyses. In the vehicle-treated HF group, cardiotoxicity resulted in decreased cardiac Na+, K+-ATPase and SERCA activities, GSH contents and caveolin-3 levels, while plasma LDH, CK, and lysosomal enzyme activities and cardiac MDA and Myeloperoxidase (MPO) activities were found to be increased. On the other hand, melatonin treatment reversed all the functional and biochemical changes. The present results demonstrate that Mel ameliorates ischemic heart failure in rats. These observations highlight that melatonin is a promising supplement for improving defense mechanisms in the heart against oxidative stress caused by heart failure.
dc.identifier.citationSehirli A. O. , Koyun D., TETİK Ş., ÖZSAVCI D., YIGINER O., ÇETİNEL Ş., Tok O. E. , Kaya Z., AKKİPRİK M., Kilic E., et al., -Melatonin protects against ischemic heart failure in rats-, JOURNAL OF PINEAL RESEARCH, cilt.55, ss.138-148, 2013
dc.identifier.doi10.1111/jpi.12054
dc.identifier.scopus84885177073
dc.identifier.trdizintrdizin
dc.identifier.urihttp://hdl.handle.net/20.500.12645/26713
dc.identifier.wosWOS:000322744600004
dc.titleMelatonin protects against ischemic heart failure in rats
dc.typeArticle
dspace.entity.typePublication
local.avesis.idbe9de72d-8823-4110-9520-fdb579fed84d
local.publication.isinternational1
relation.isAuthorOfPublication1782a1d6-af66-4554-b261-d8e28174f7b8
relation.isAuthorOfPublication.latestForDiscovery1782a1d6-af66-4554-b261-d8e28174f7b8
Files
Collections
Silinecekler