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Serum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis.

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dc.contributor.authorTORUN, EMEL
dc.contributor.authorGEDIK, AH
dc.contributor.authorCakir, ERKAN
dc.contributor.authorUMUTOGLU, T
dc.contributor.authorGOK, O
dc.contributor.authorKILIC, U
dc.contributor.institutionauthorTORUN, EMEL
dc.contributor.institutionauthorÇAKIR, ERKAN
dc.date.accessioned2019-10-05T22:16:20Z
dc.date.available2019-10-05T22:16:20Z
dc.date.issued2014-01-01
dc.description.abstractObjectives: The aim of this study was to determine the oxidative stress and paraoxonase 1 (PON1) levels in children with pulmonary tuberculosis (TB) compared to healthy controls, and to examine the association of demographical with oxidative stress. Subjects and methods: Forty children diagnosed with pulmonary TB and 40 age- and gender-matched healthy controls were enrolled in the study. Serum total antioxidant status (TAS), total oxidant status (TOS) and PON1 levels were measured. The oxidative stress index (OSI) was calculated to indicate the degree of oxidative stress. Results: The TAS levels were lower (1.73 ± 0.5 vs. 2.54 ± 1.2 μmol Trolox Eq/l) while TOS levels were significantly higher (26.9 ± 14.4 vs. 13.4 ± 7.7 μmol H2O2 Eq/l) in the TB group than in the controls (p < 0.001). The OSI was significantly higher in the TB group than in the controls (21.2 ± 5.1 vs. 6.5 ± 4.9 units, p = 0.006). Serum PON1 levels were significantly lower in the TB group than in the controls (14.2 ± 13.2 vs. 28.4 ± 17.3 U/l, p < 0.001). The lower PON1 levels correlated with TAS and OSI levels but not with anthropometric parameters (r = 0.264, p = 0.018 and r = -0.255, p = 0.023, respectively). Conclusion: The TOS and OSI levels were higher and the TAS and PON1 levels were lower in pediatric patients with pulmonary TB when compared to healthy controls. This indicates greater oxidative stress in the patients.en
dc.identifier10.4328/jcam.847
dc.identifier.citationTORUN E., GEDIK A., Cakir E., UMUTOGLU T., GOK O., KILIC U., -Serum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis.-, Medical principles and practice : international journal of the Kuwait University, Health Science Centre, cilt.23, ss.426-31, 2014
dc.identifier.doi10.1159/000363700
dc.identifier.pubmed25034194
dc.identifier.scopus84927693011
dc.identifier.urihttps://hdl.handle.net/20.500.12645/9267
dc.identifier.wosWOS:000341963000005
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleSerum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis.
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameJournal of Clinical and Analytical Medicine
local.avesis.ide68a546e-5e79-43a7-8645-e4d52b6f4ef5
local.avesis.response9143
local.publication.goal03 - Sağlık ve Kaliteli Yaşam
local.publication.isinternational1
relation.isAuthorOfPublication12c436eb-39a7-43ce-b99f-c585a4499848
relation.isAuthorOfPublication548bd03a-cc9a-4b60-9886-1787eb5f6a4d
relation.isAuthorOfPublication.latestForDiscovery548bd03a-cc9a-4b60-9886-1787eb5f6a4d
relation.isGoalOfPublication9c198c48-b603-4e2f-8366-04edcfc1224c
relation.isGoalOfPublication.latestForDiscovery9c198c48-b603-4e2f-8366-04edcfc1224c
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