Publication:
Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia

dc.contributor.authorAYDIN S.
dc.contributor.authorMERT A.
dc.contributor.authorYILMAZ M.
dc.contributor.authorAl Maslamani M.
dc.contributor.authorRahimi B. A.
dc.contributor.authorAyoade F.
dc.contributor.authorEl-Kholy A.
dc.contributor.authorBelitova M.
dc.contributor.authorSengel B. E.
dc.contributor.authorJalal S.
dc.contributor.authoret al.
dc.contributor.institutionauthorAKKOYUNLU, YASEMİN
dc.date.accessioned2024-01-30T21:50:45Z
dc.date.available2024-01-30T21:50:45Z
dc.date.issued2024-01-01
dc.description.abstractBackground: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection.Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021.Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020).Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia.
dc.identifier.citationAYDIN S., MERT A., YILMAZ M., Al Maslamani M., Rahimi B. A., Ayoade F., El-Kholy A., Belitova M., Sengel B. E., Jalal S., et al., "Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia", MYCOSES, cilt.67, sa.1, 2024
dc.identifier.doi10.1111/myc.13687
dc.identifier.issn0933-7407
dc.identifier.issue1
dc.identifier.pubmed38214425
dc.identifier.scopus85181705067
dc.identifier.urihttps://hdl.handle.net/20.500.12645/38994
dc.identifier.volume67
dc.identifier.wosWOS:001135697400001
dc.relation.ispartofMYCOSES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectDermatoloji
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectMikoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectDermatology
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectPlant Protection
dc.subjectPhytopathology
dc.subjectMycology
dc.subjectHealth Sciences
dc.subjectDERMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMİKOLOJİ
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectDERMATOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectMYCOLOGY
dc.subjectPLANT & ANIMAL SCIENCE
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectKüçük hayvanlar
dc.subjectSmall Animals
dc.titleUnderstanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia
dc.typearticle
dspace.entity.typePublication
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